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公开(公告)号：US08658675B2
公开(公告)日：2014-02-25
申请号：US13383619
申请日：2010-07-15
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： The invention relates to pyridine derivatives of Formula (I), wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及式（I）的吡啶衍生物，其中A，R 1，R 2，R 3和R 4如说明书中所述，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
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公开(公告)号：US09133179B2
公开(公告)日：2015-09-15
申请号：US13980764
申请日：2012-01-18
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4439 , A61P37/00
CPC分类号： C07D413/14 , C07D413/04
摘要： The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及式（I）的吡啶衍生物，其中A，R 1，R 2，R 3和R 4如说明书中所述，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
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公开(公告)号：US20130303514A1
公开(公告)日：2013-11-14
申请号：US13980764
申请日：2012-01-18
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： C07D413/14 , C07D413/04
CPC分类号： C07D413/14 , C07D413/04
摘要： The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及式（I）的吡啶衍生物，其中A，R 1，R 2，R 3和R 4如说明书中所述，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
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公开(公告)号：US20120108638A1
公开(公告)日：2012-05-03
申请号：US13383619
申请日：2010-07-15
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Keith Morrison , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： A61K31/4439 , A61P35/04 , A61P35/00 , C07D413/04 , A61P37/06
CPC分类号： C07D413/04
摘要： The invention relates to pyridine derivatives of Formula (I), wherein A, R1, R2, R3, and R4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及式（I）的吡啶衍生物，其中A，R 1，R 2，R 3和R 4如说明书中所述，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
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公开(公告)号：US08598208B2
公开(公告)日：2013-12-03
申请号：US12673918
申请日：2008-08-14
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner , Jorg Velker
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner , Jorg Velker
IPC分类号： A61K31/443 , C07D401/14
CPC分类号： C07D413/14 , C07D417/14
摘要： The invention relates to novel pyridine derivatives of formula (D, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents and the other substituents are as defined in the claims.
摘要翻译： 本发明涉及式（D的新型吡啶衍生物及其制备及其作为药物活性化合物的用途，所述化合物特别用作免疫调节剂，其中A代表其它取代基如权利要求中所定义。
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公开(公告)号：US08299086B2
公开(公告)日：2012-10-30
申请号：US12738110
申请日：2008-10-31
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： C07D413/04 , A61K31/506
CPC分类号： C07D413/04 , C07D417/04
摘要： The invention relates to novel pyrimidine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I) wherein A represents Formula (II), Formula (III), Formula (IV), Formula (V), Formula (VI), Formula (VII), Formula (VIII) or Formula (IX)
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公开(公告)号：US20100261702A1
公开(公告)日：2010-10-14
申请号：US12747280
申请日：2008-12-09
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： A61K31/4245 , C07D413/04 , A61K31/5377 , C07D413/14 , A61P1/00 , A61P37/00 , A61P11/06 , A61P19/02 , A61P13/12 , A61P3/10 , A61P1/16
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to novel thiophene derivatives (1), their preparation and their use as pharmaceutically active compounds.Said compounds particularly act as immunomodulating agents. Formula (I).
摘要翻译： 本发明涉及新的噻吩衍生物（1），其制备及其作为药物活性化合物的用途。所述化合物特别用作免疫调节剂。 式（I）。
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公开(公告)号：US08410151B2
公开(公告)日：2013-04-02
申请号：US12920574
申请日：2009-03-03
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： C07D271/06
摘要： The invention relates to novel aminomethyl benzene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及新型氨基甲基苯衍生物，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
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公开(公告)号：US20110028448A1
公开(公告)日：2011-02-03
申请号：US12920569
申请日：2009-03-03
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： A61K31/4439 , C07D413/04 , C07D413/14 , A61P11/06 , A61P29/00 , A61P17/06 , A61P25/00 , A61P3/10 , A61P35/00 , A61P35/04
CPC分类号： C07D413/04
摘要： The invention relates to pyridine compounds, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
摘要翻译： 本发明涉及吡啶化合物，其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。
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公开(公告)号：US08148410B2
公开(公告)日：2012-04-03
申请号：US12747280
申请日：2008-12-09
申请人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
发明人： Martin Bolli , Cyrille Lescop , Boris Mathys , Claus Mueller , Oliver Nayler , Beat Steiner
IPC分类号： A61K31/381 , A61K31/4245 , A61K31/41 , C07D271/06 , C07D271/10 , C07D285/16 , C07D409/04
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to novel thiophene derivatives (I), their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula (I).
摘要翻译： 本发明涉及新的噻吩衍生物（I），其制备及其作为药物活性化合物的用途。 所述化合物特别充当免疫调节剂。 式（I）。
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