公开(公告)号：US20080254040A1

公开(公告)日：2008-10-16

申请号：US12140661

申请日：2008-06-17

申请人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

发明人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

IPC分类号： A61K39/395 ,  A61K31/496 ,  A61K38/19 ,  A61K31/553 ,  A61P35/00 ,  A61K31/517 ,  A61K38/43

CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/517 ,  A61K31/553 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

摘要翻译： 本发明涉及用于治疗涉及骨髓瘤细胞的细胞增殖，迁移或凋亡或血管发生的疾病的药物组合。 本发明还涉及一种治疗所述疾病的方法，包括以提供添加剂和协同效应的比例共同给予有效量的特定活性化合物和/或与放射治疗共同给药，以及组合 使用这些特定化合物和/或放射治疗来制造相应的药物组合制剂。

公开(公告)号：US20140057898A1

公开(公告)日：2014-02-27

申请号：US14071166

申请日：2013-11-04

申请人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

发明人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

IPC分类号： A61K31/496 ,  A61K31/553

CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/517 ,  A61K31/553 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

摘要翻译： 本发明涉及用于治疗涉及骨髓瘤细胞的细胞增殖，迁移或凋亡或血管发生的疾病的药物组合。 本发明还涉及一种治疗所述疾病的方法，包括以提供添加剂和协同效应的比例共同给予有效量的特定活性化合物和/或与放射治疗共同给药，以及组合 使用这些特定化合物和/或放射治疗来制造相应的药物组合制剂。

公开(公告)号：US20110171289A1

公开(公告)日：2011-07-14

申请号：US12912110

申请日：2010-11-09

申请人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

发明人： Martin Friedrich STEFANIC ,  Frank HILBERG ,  Gerd MUNZERT ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

IPC分类号： A61K9/127 ,  A61K31/502 ,  A61K31/5377 ,  A61K31/395 ,  A61K31/506 ,  A61K31/675 ,  A61K33/24 ,  A61K31/7008 ,  A61K31/66 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7076 ,  A61K38/14 ,  A61K38/21 ,  A61K31/57 ,  A61K38/20 ,  A61K38/16 ,  A61K39/395 ,  A61P35/00 ,  A61P35/02

CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/517 ,  A61K31/553 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

公开(公告)号：US20110136826A1

公开(公告)日：2011-06-09

申请号：US12912098

申请日：2010-11-15

申请人： Frank HILBERG ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

发明人： Frank HILBERG ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

IPC分类号： A61K31/517 ,  A61P35/00

CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/517 ,  A61K31/553 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

摘要翻译： 本发明涉及用于治疗涉及骨髓瘤细胞的细胞增殖，迁移或凋亡或血管发生的疾病的药物组合。 本发明还涉及一种治疗所述疾病的方法，包括以提供添加剂和协同效应的比例共同给予有效量的特定活性化合物和/或与放射治疗共同给药，以及组合 使用这些特定化合物和/或放射治疗来制造相应的药物组合制剂。

公开(公告)号：US20110039863A1

公开(公告)日：2011-02-17

申请号：US12912090

申请日：2010-10-26

申请人： Frank HILBERG ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

发明人： Frank HILBERG ,  Flavio SOLCA ,  Anke BAUM ,  Jacobus C.A. van MEEL

IPC分类号： A61K31/496 ,  A61P35/00

CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/517 ,  A61K31/553 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. The invention also relates to a method for the treatment of said diseases, comprising co-administration of effective amounts of specific active compounds and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of these specific compounds and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

公开(公告)号：US20130178487A1

公开(公告)日：2013-07-11

申请号：US13766914

申请日：2013-02-14

申请人： Flavio SOLCA ,  Andree AMELSBERG ,  Jacobus C.A. van MEEL ,  Anke BAUM ,  Gerd STEHLE

发明人： Flavio SOLCA ,  Andree AMELSBERG ,  Jacobus C.A. van MEEL ,  Anke BAUM ,  Gerd STEHLE

IPC分类号： A61K31/517

CPC分类号： A61K31/517 ,  A61K31/553 ,  A61K33/24

摘要： The present invention relates to the use of quinazolines of formula (I), wherein the groups Ra to Rd have the meanings given in the claims and specification, in cancer therapy.