公开(公告)号：US08759308B2

公开(公告)日：2014-06-24

申请号：US12845521

申请日：2010-07-28

申请人： Martin Gleave ,  Burkhard Jansen ,  Ioannis P Trougakos ,  Efstathios Gonos ,  Maxim Signaevsky ,  Eliana Beraldi

发明人： Martin Gleave ,  Burkhard Jansen ,  Ioannis P Trougakos ,  Efstathios Gonos ,  Maxim Signaevsky ,  Eliana Beraldi

IPC分类号： A61K48/00

CPC分类号： C12N15/113 ,  A61K31/712 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease. These sequences target clusterin, IGFBP-5, IGFBP-2, both IGFBP-2 and -5 simultaneously, Mitf, and B-raf. The invention further provides for the use of these RNAi sequences in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease, and a method of treating such conditions through the administration of the RNA molecules with RNAi activity to an individual, including a human individual in need of such treatment.

摘要翻译： 可用作治疗各种类型癌症的RNAi序列，包括前列腺癌，肉瘤如骨肉瘤，肾细胞癌，乳腺癌，膀胱癌，肺癌，结肠癌，卵巢癌，间变性大细胞淋巴瘤和黑素瘤 ; 和阿尔茨海默病。 这些序列同时靶向簇蛋白，IGFBP-5，IGFBP-2，IGFBP-2和-5两者，Mitf和B-raf。 本发明进一步提供这些RNAi序列用于治疗各种类型的癌症，包括前列腺癌，肉瘤如骨肉瘤，肾细胞癌，乳腺癌，膀胱癌，肺癌，结肠癌，卵巢癌，间变性大 细胞淋巴瘤和黑素瘤; 和阿尔茨海默病，以及通过向包括需要这种治疗的人的个体的个体施用具有RNAi活性的RNA分子来治疗这些病症的方法。

公开(公告)号：US07820635B2

公开(公告)日：2010-10-26

申请号：US12116083

申请日：2008-05-06

申请人： Martin Gleave ,  Burkhard Jansen ,  Ioannis P Trougakos ,  Efstathios Gonos ,  Maxim Signaevsky ,  Eliana Beraldi

发明人： Martin Gleave ,  Burkhard Jansen ,  Ioannis P Trougakos ,  Efstathios Gonos ,  Maxim Signaevsky ,  Eliana Beraldi

IPC分类号： A61K48/00

CPC分类号： C12N15/113 ,  A61K31/712 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease. These sequences target clusterin, IGFBP-5, IGFBP-2, both IGFBP-2 and -5 simultaneously, Mitf, and B-raf. The invention further provides for the use of these RNAi sequences in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease, and a method of treating such conditions through the administration of the RNA molecules with RNAi activity to an individual, including a human individual in need of such treatment.

摘要翻译： 可用作治疗各种类型癌症的RNAi序列，包括前列腺癌，肉瘤如骨肉瘤，肾细胞癌，乳腺癌，膀胱癌，肺癌，结肠癌，卵巢癌，间变性大细胞淋巴瘤和黑素瘤 ; 和阿尔茨海默病。 这些序列同时靶向簇蛋白，IGFBP-5，IGFBP-2，IGFBP-2和-5两者，Mitf和B-raf。 本发明进一步提供这些RNAi序列用于治疗各种类型的癌症，包括前列腺癌，肉瘤如骨肉瘤，肾细胞癌，乳腺癌，膀胱癌，肺癌，结肠癌，卵巢癌，间变性大 细胞淋巴瘤和黑素瘤; 和阿尔茨海默病，以及通过向包括需要这种治疗的人的个体的个体施用具有RNAi活性的RNA分子来治疗这些病症的方法。