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    Combination of Protein Forms for Hornfly Vaccination
    1.
    发明申请
    Combination of Protein Forms for Hornfly Vaccination 审中-公开
    蛋白质形式用于蜻蜓疫苗接种的组合

    公开(公告)号：US20120263742A1

    公开(公告)日：2012-10-18

    申请号：US13438263

    申请日：2012-04-03

    申请人： Mary S. Cupp ,  Eddie W. Cupp ,  Christine Navarre ,  Dunhua Zhang ,  Latora Todd ,  Eugene Blair

    发明人： Mary S. Cupp ,  Eddie W. Cupp ,  Christine Navarre ,  Dunhua Zhang ,  Latora Todd ,  Eugene Blair

    IPC分类号： A61K39/00 ,  A61P33/14 ,  A61P37/04

    CPC分类号： A61K39/0003 ,  A61K2039/552

    摘要： Thrombostasin is an anti-clotting protein found in saliva of Haematobia irritans. Disclosed herein are studies testing blood uptake of horn flies feeding on cattle which confirm the association of ts genotype with blood uptake of horn flies. Blood uptake volumes of homozygous ts10 horn flies were lower than those of other ts genotypes when fed on control cattle. Cattle vaccinated with recombinant protein isoforms rTS9 or rTB8 resisted horn fly feeding by yielding lower blood volumes compared to flies feeding on control cattle. The impact of vaccination varied by ts genotype of flies. Cattle vaccinated with isoforms rTS9 resisted flies of ts2, ts9, and tb8 genotype. Vaccination with isoforms rTB8 produced resistance to ts8, ts9 and tb8 genotype flies. Horn flies of genotype ts10 were not affected with either TS isoforms and fed well on rTS9 and rTB9 vaccinated as on control-vaccinated cattle.

    摘要翻译： 凝血酶是一种抗凝血蛋白质，在荨麻疹的唾液中发现。 本文中公开的是测试对牛饲养的角蝇的血液摄取的研究，其确认ts基因型与角蝇的血液摄取的关联。 在对照牛饲养时，纯合ts10号角蝇的摄血量低于其他ts基因型。 用重组蛋白质同种型rTS9或rTB8接种的牛与对照牛饲喂的苍蝇相比，通过产生较低的血容量抵抗角飞喂养。 疫苗的影响因苍蝇的ts基因型而异。 用同种型rTS9接种的牛抗ts2，ts9和tb8基因型的苍蝇。 用同种型rTB8疫苗接种产生对ts8，ts9和tb8基因型苍蝇的抗性。 基因型ts10的角蝇不受TS同种型的影响，并且在对照接种牛的rTS9和rTB9上接种良好。

    Combination of protein forms for hornfly vaccination
    2.
    发明授权
    Combination of protein forms for hornfly vaccination 有权
    蛋白质形式用于角膜接种的组合

    公开(公告)号：US09101557B2

    公开(公告)日：2015-08-11

    申请号：US13438263

    申请日：2012-04-03

    申请人： Mary S. Cupp ,  Eddie W. Cupp ,  Christine Navarre ,  Dunhua Zhang ,  Latora W. Todd Jackson ,  Eugene Blair

    发明人： Mary S. Cupp ,  Eddie W. Cupp ,  Christine Navarre ,  Dunhua Zhang ,  Latora W. Todd Jackson ,  Eugene Blair

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0003 ,  A61K2039/552

    摘要： Thrombostasin is an anti-clotting protein found in saliva of Haematobia irritans. Disclosed herein are studies testing blood uptake of horn flies feeding on cattle which confirm the association of ts genotype with blood uptake of horn flies. Blood uptake volumes of homozygous ts10 horn flies were lower than those of other ts genotypes when fed on control cattle. Cattle vaccinated with recombinant protein isoforms rTS9 or rTB8 resisted horn fly feeding by yielding lower blood volumes compared to flies feeding on control cattle. The impact of vaccination varied by ts genotype of flies. Cattle vaccinated with isoforms rTS9 resisted flies of ts2, ts9, and tb8 genotype. Vaccination with isoforms rTB8 produced resistance to ts8, ts9 and tb8 genotype flies. Horn flies of genotype ts10 were not affected with either TS isoforms and fed well on rTS9 and rTB9 vaccinated as on control-vaccinated cattle.

    摘要翻译： 凝血酶是一种抗凝血蛋白质，在荨麻疹的唾液中发现。 本文中公开的是测试对牛饲养的角蝇的血液摄取的研究，其确认ts基因型与角蝇的血液摄取的关联。 在对照牛饲养时，纯合ts10号角蝇的摄血量低于其他ts基因型。 用重组蛋白质同种型rTS9或rTB8接种的牛与对照牛饲喂的苍蝇相比，通过产生较低的血容量抵抗角飞喂养。 疫苗的影响因苍蝇的ts基因型而异。 用同种型rTS9接种的牛抗ts2，ts9和tb8基因型的苍蝇。 用同种型rTB8疫苗接种产生对ts8，ts9和tb8基因型苍蝇的抗性。 基因型ts10的角蝇不受TS同种型的影响，并且在对照接种牛的rTS9和rTB9上接种良好。

    Protein from horn fly saliva that disrupts hemostasis
    3.
    发明授权
    Protein from horn fly saliva that disrupts hemostasis 有权
    来自角飞唾液的蛋白质会破坏止血

    公开(公告)号：US07211652B2

    公开(公告)日：2007-05-01

    申请号：US10996248

    申请日：2004-11-23

    申请人： Mary S. Cupp ,  Dunhua Zhang ,  Eddie W. Cupp

    发明人： Mary S. Cupp ,  Dunhua Zhang ,  Eddie W. Cupp

    IPC分类号： A61K38/17 ,  C07K14/435

    CPC分类号： C07K14/81 ,  A61K38/00 ,  C07K14/43577 ,  C07K2319/21 ,  Y10S530/858

    摘要： Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins that disrupt platelet aggregation. Also provided are nucleotide sequences encoding the proteins. The exemplary haematollogen protein was isolated from the salivary glands of Haematobia irritans. The compositions are useful as veterinary vaccines in prevention of blood-feeding in cattle by the infesting horn fly and are also useful in treatment of thrombosis.

    摘要翻译： 提供了防止血液感染牛的组合物和方法，针对破坏血小板聚集的分离的蛋白质。 还提供了编码蛋白质的核苷酸序列。 从Haematobia irritans的唾液腺中分离出示例性的血液生成蛋白。 该组合物可用作兽用疫苗，用于通过感染的角飞防止牛中的血液喂养，并且还可用于治疗血栓形成。