公开(公告)号：US4894457A

公开(公告)日：1990-01-16

申请号：US135392

申请日：1987-12-21

申请人： Masaaki Kubo ,  Hiroshi Umezawa ,  Kazuhiro Okura

发明人： Masaaki Kubo ,  Hiroshi Umezawa ,  Kazuhiro Okura

IPC分类号： C07B61/00 ,  C07D471/04

CPC分类号： C07D471/04

摘要： A 7-bromo-.beta.-carboline compound of the formula (I): ##STR1## wherein R.sup.1 =H or C.sub.1 -C.sub.5 alkyl and R.sup.2 =C.sub.1 -C.sub.5 alkyl or benzyl, is produced by reacting a .beta.-carboline compound of the formula (II): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above and R.sup.3 =H, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy or benzyloxy, with a brominating agent in an organic solvent in the presence of an alkalic and then hydrolyzing the resultant procursory 7-bromo-.beta.-carboline compound of the formula (III): ##STR3## is a solvent in the presence of a mineral acid.

公开(公告)号：US4760195A

公开(公告)日：1988-07-26

申请号：US78825

申请日：1987-07-28

申请人： Masaaki Kubo ,  Kazuhiro Okura

发明人： Masaaki Kubo ,  Kazuhiro Okura

IPC分类号： B01J19/12 ,  C07C41/48 ,  C07C43/313 ,  C07C45/00 ,  C07C45/63 ,  C07C47/14 ,  C07C47/17 ,  C07C67/00 ,  C07D317/08 ,  C07D317/16 ,  C07D319/06

CPC分类号： B01J19/123 ,  C07C41/48 ,  C07C45/63 ,  C07C47/14

摘要： A 5-bromo-1-pentanal compound of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 respectively represent, independently from each other, a member selected from the group consisting of a hydrogen atom and alkyl radicals having 1 to 7 carbon atoms, or an acetal derivative of said 5-bromo-1-pentanal compound, is produced by subjecting a starting compound selected from the group consisting of 4-pentenal compounds of the formula (II): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and acetal derivatives of the above-mentioned compounds, to a free radical addition reaction with hydrogen bromide in a liquid medium at a temperature of 10.degree. C. to 60.degree. C.; in the presence of a free radical initiator or by irradiating ultraviolet rays to the reaction mixture, and by collecting the resultant reaction product from the reaction mixture.