公开(公告)号：US20080020988A1

公开(公告)日：2008-01-24

申请号：US11728283

申请日：2007-03-22

申请人： Masahiro Sakanaka ,  Nobuji Maeda ,  Junya Tanaka ,  Kimihiko Nakata

发明人： Masahiro Sakanaka ,  Nobuji Maeda ,  Junya Tanaka ,  Kimihiko Nakata

IPC分类号： A61K31/7028 ,  A61P43/00 ,  C07J41/00

CPC分类号： A61K31/00 ,  A61K31/704 ,  A61K36/258 ,  C07J17/00

摘要： The present invention provides medicinal or pharmaceutical compositions and preparations for administration, which are useful as cytoprotective agents and a remedy for neurotrauma, comprising ginseng, its extract, ginseng components, metabolites thereof or salts thereof (for example, red ginseng powder or components thereof). More particularly, the present invention provides medicinal or pharmaceutical compositions for inhibiting apoptosis or apoptosis-like cell death, medicinal or pharmaceutical compositions for promoting the expression of a cell death-suppressing gene product BCl-xL, or preparations for oral or intravenous administration, comprising ginseng, its extracts, ginseng components, metabolites thereof or salts thereof preferably at low concentrations. These medicinal or pharmaceutical compositions and/or preparations for administration are characterized by containing, as the active ingredient(s), ginseng, its extracts, ginseng components, metabolites thereof or salts thereof at low concentrations. These drugs are useful for therapy, prevention or treatment of brain and nervous diseases, heart diseases, etc.

摘要翻译： 本发明提供可用作细胞保护剂和神经损伤补救剂的医药或药物组合物和药物组合物和制剂，其包括人参，其提取物，人参组分，其代谢物或其盐（例如红参粉或其组分） 。 更具体地说，本发明提供用于抑制细胞凋亡或细胞凋亡样细胞死亡的药物或药物组合物，用于促进细胞死亡抑制基因产物BCl-xL1表达的药物或药物组合物，或 用于口服或静脉内给药的制剂，其包含人参，其提取物，人参成分，其代谢物或其盐，优选低浓度。 这些药物或药物组合物和/或给药制剂的特征在于，以低浓度含有作为活性成分的人参，其提取物，人参成分，其代谢物或其盐。 这些药物可用于治疗，预防或治疗脑和神经疾病，心脏病等。

公开(公告)号：US07235267B1

公开(公告)日：2007-06-26

申请号：US10070209

申请日：2000-06-22

申请人： Masahiro Sakanaka ,  Nobuji Maeda ,  Junya Tanaka ,  Kimihiko Nakata

发明人： Masahiro Sakanaka ,  Nobuji Maeda ,  Junya Tanaka ,  Kimihiko Nakata

IPC分类号： A61K36/258 ,  A61K36/00

CPC分类号： A61K31/00 ,  A61K31/704 ,  A61K36/258 ,  C07J17/00

摘要： The present invention provides medicinal or pharmaceutical compositions and preparations for administration, which are useful as cytoprotective agents and a remedy for neurotrauma, comprising ginseng, its extract, ginseng components, metabolites thereof or salts thereof (for example, red ginseng powder or components thereof). More particularly, the present invention provides medicinal or pharmaceutical compositions for inhibiting apoptosis or apoptosis-like cell death, medicinal or pharmaceutical compositions for promoting the expression of a cell death-suppressing gene product Bcl-xL, or preparations for oral or intravenous administration, comprising ginseng, its extracts, ginseng components, metabolites thereof or salts thereof preferably at low concentrations. These medicinal or pharmaceutical compositions and/or preparations for administration are characterized by containing, as the active ingredient(s), ginseng, its extracts, ginseng components, metabolites thereof or salts thereof at low concentrations. These drugs are useful for therapy, prevention or treatment of brain and nervous diseases, heart diseases, etc.

摘要翻译： 本发明提供可用作细胞保护剂和神经损伤补救剂的医药或药物组合物和药物组合物和制剂，其包括人参，其提取物，人参组分，其代谢物或其盐（例如红参粉或其组分） 。 更具体地说，本发明提供用于抑制细胞凋亡或细胞凋亡样细胞死亡的药物或药物组合物，用于促进细胞死亡抑制基因产物Bcl-xL1表达的药物或药物组合物，或 用于口服或静脉内给药的制剂，其包含人参，其提取物，人参成分，其代谢物或其盐，优选低浓度。 这些药物或药物组合物和/或给药制剂的特征在于，以低浓度含有作为活性成分的人参，其提取物，人参成分，其代谢物或其盐。 这些药物可用于治疗，预防或治疗脑和神经疾病，心脏病等。