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    NOVEL 5-FLUOROURACIL DERIVATIVE
    1.
    发明申请
    NOVEL 5-FLUOROURACIL DERIVATIVE 有权
    新的5-氟尿嘧啶衍生物

    公开(公告)号：US20120232103A1

    公开(公告)日：2012-09-13

    申请号：US13419691

    申请日：2012-03-14

    申请人： Masakazu FUKUSHIMA ,  Shozo Yamada ,  Ryo Oyama

    发明人： Masakazu FUKUSHIMA ,  Shozo Yamada ,  Ryo Oyama

    IPC分类号： A61K31/513 ,  A61P35/00 ,  C07D401/14

    CPC分类号： C07D401/14 ,  Y02P20/55

    摘要： The present invention provides a novel antimetabolic anticancer agent that has an excellent balance between antitumor effect and toxicity. Specifically, the present invention provides a medicament containing, as an active ingredient, a 5-fluorouracil derivative represented by Formula (I) or a salt thereof: wherein R1 represents a hydrogen atom or a protecting group of a hydroxy group, R2 represents a lower alkoxy-lower alkyl group or a tetrahydrofuranyl group, X represents a carbon atom or a nitrogen atom, and Y represents a halogen atom or a cyano group.

    摘要翻译： 本发明提供了抗肿瘤效果和毒性之间具有优异平衡性的新型抗代谢抗癌剂。 具体而言，本发明提供含有作为活性成分的式（I）表示的5-氟尿嘧啶衍生物或其盐的药物：其中，R1表示氢原子或羟基的保护基，R2表示低级 烷氧基 - 低级烷基或四氢呋喃基，X表示碳原子或氮原子，Y表示卤素原子或氰基。

    POTENTIATOR OF RADIATION THERAPY
    3.
    发明申请
    POTENTIATOR OF RADIATION THERAPY 有权
    辐射治疗的潜力

    公开(公告)号：US20120010165A1

    公开(公告)日：2012-01-12

    申请号：US13242432

    申请日：2011-09-23

    申请人： Masakazu FUKUSHIMA

    发明人： Masakazu FUKUSHIMA

    IPC分类号： A61K31/513 ,  A61K31/7072 ,  A61P35/00

    CPC分类号： C07D403/06 ,  A61K31/513 ,  A61K31/7072

    摘要： To provide a radiation therapy potentiator, which, when employed in combination with cancer radiation therapy, can reduce radiation dose and can mitigate adverse effects.The invention provides a radiation therapy potentiator containing, as an effective ingredient, a uracil derivative represented by formula (1) (wherein R1 represents a halogen atom or a cyano group; and R2 represents a 4- to 8-membered heterocyclic group having 1 to 3 nitrogen atoms and optionally having as a substituent a lower alkyl group, an imino group, a hydroxyl group, a hydroxymethyl group, a methanesulfonyloxy group, or an amino group; an amidinothio group in which a hydrogen atom attached to a nitrogen atom may be substituted by a lower alkyl group; a guanidino group in which a hydrogen atom attached to a nitrogen atom may be substituted by a lower alkyl group or a cyano group; a lower alkylamidino group; or a 1-pyrrolidinylmethyl group) or a pharmaceutically acceptable salt thereof.

    摘要翻译： 提供放射治疗增强剂，当与癌症放射治疗组合使用时，可以减少辐射剂量并减轻不良反应。 本发明提供一种放射治疗增效剂，其含有作为有效成分的式（1）表示的尿嘧啶衍生物（其中，R1表示卤素原子或氰基; R2表示具有1〜 3个氮原子，任选具有低级烷基，亚氨基，羟基，羟甲基，甲磺酰氧基或氨基作为取代基;其中与氮原子连接的氢原子可以是 被低级烷基取代;其中与氮原子连接的氢原子可以被低级烷基或氰基取代的胍基，低级烷基脒基或1-吡咯烷基甲基）或其药学上可接受的盐 其中。