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    7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs
    6.
    发明授权
    7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs 失效
    7-氧杂双环庚烷取代异羟肟酸前列腺素类似物

    公开(公告)号：US4734425A

    公开(公告)日：1988-03-29

    申请号：US920006

    申请日：1986-10-17

    申请人： Masami Nakane ,  Joyce Reid

    发明人： Masami Nakane ,  Joyce Reid

    IPC分类号： A61K31/34 ,  A61P7/02 ,  A61P11/08 ,  C07D493/08 ,  C07D307/00 ,  A61K31/41 ,  C07D405/06

    CPC分类号： C07D493/08

    摘要： 7-Oxabicycloheptane substituted hydroxamic acid prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH.sub.2 -CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR2## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; q is 1 to 12, R.sup.1 is H or OH; R.sup.2 is OH or H, provided that one of R.sup.1 and R.sup.2 is OH and the other is H; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, ##STR3## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

    摘要翻译： 提供7-氧杂二环庚烷取代的异羟肟酸前列腺素类似物，其结构式为：其中A为-CH = CH-或-CH 2 -CH 2 - ; n为1至5; R为CO 2 H，CO 2烷基，CO 2碱金属，CO 2多羟基胺盐，-CH 2 OH，其中R 4和R 5相同或不同，为H，低级烷基，羟基，低级烷氧基或芳基，R 4和R 5中的至少一个为其它 羟基和低级烷氧基; q为1至12，R1为H或OH; R2是OH或H，条件是R1和R2之一是OH，另一个是H; 并且R 3是H，低级烷基，低级烯基，低级炔基，芳基，芳基烷基，低级烷氧基，芳氧基，芳基烷氧基，氨基，烷基氨基芳基氨基，芳烷基氨基，（其中n'是0,1或2），烷基氨基烷基，芳基氨基烷基 芳基烷基氨基烷基，烷氧基烷基，芳氧基烷基或芳基烷氧基烷基。 这些化合物是可用于例如治疗血栓形成疾病的心血管药。

    Bisthioamide-7-oxabicycloheptane prostaglandin analogs
    7.
    发明授权
    Bisthioamide-7-oxabicycloheptane prostaglandin analogs 失效
    双硫酰胺-7-氧杂双环庚烷前列腺素类似物

    公开(公告)号：US4738978A

    公开(公告)日：1988-04-19

    申请号：US928947

    申请日：1986-11-10

    申请人： Masami Nakane ,  Joyce Reid

    发明人： Masami Nakane ,  Joyce Reid

    IPC分类号： C07D493/08 ,  C07D307/00 ,  A61K31/34 ,  A61K31/41 ,  C07D405/06

    CPC分类号： C07D493/08

    摘要： Bisthioamide-7-oxabicycloheptane prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 lower alkyl or ##STR2## q is 1 to 12; and R.sup.1 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-aryl-S-, arylalkyl-S-, ##STR3## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

    摘要翻译： 提供具有结构式为其中A为-CH = CH-或-CH 2 -CH 2 - 的结构式的二异丙酰胺-7-氧杂双环庚烷前列腺素类似物; n为1至5; R是CO 2 H，CO 2低级烷基或者q是1至12; R 1为H，低级烷基，低级烯基，低级炔基，芳基，芳基烷基，低级烷氧基，芳氧基，芳基烷氧基，氨基，烷基氨基芳基氨基，芳基烷基氨基，低级烷基-S-芳基-S-，芳基烷基-S-， （其中n'为0,1或2），烷基氨基烷基，芳基氨基烷基，芳基烷基氨基烷基，烷氧基烷基，芳氧基烷基或芳基烷氧基烷基。 这些化合物是可用于例如治疗血栓形成疾病的心血管药。

    7-oxabicycloheptane substituted diacid diamide prostaglandin analogs
    8.
    发明授权
    7-oxabicycloheptane substituted diacid diamide prostaglandin analogs 失效
    7-氧杂双环庚烷取代二酸二酰胺前列腺素类似物

    公开(公告)号：US4654356A

    公开(公告)日：1987-03-31

    申请号：US761263

    申请日：1985-08-01

    申请人： Masami Nakane ,  Joyce Reid

    发明人： Masami Nakane ,  Joyce Reid

    IPC分类号： A47F1/18 ,  A61K31/557 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P11/08 ,  C07D493/08 ,  A61K31/34 ,  C07D405/14

    CPC分类号： C07D493/08

    摘要： 7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 and R.sup.3 are the same or different and are H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy or cycloalkyl.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

    摘要翻译： 提供7-氧杂双环庚烷取代的二酸二酰胺前列腺素类似物，其结构式为：其中m为0至4; A是-CH = CH-或-CH 2 -CH 2 - ; n为1至5; Q是-CH = CH-，-CH 2 - ，或单键; R为CO 2 H，CO 2烷基，CO 2碱金属，CO 2多羟基胺盐，-CH 2 OH，其中R 4和R 5相同或不同，为H，低级烷基，羟基，低级烷氧基或芳基，R 4和R 5中的至少一个为其它 羟基和低级烷氧基; p为1〜4; R1是H或低级烷基; q为1〜12; R2和R3相同或不同，为H，低级烷基，低级烯基，低级炔基，芳基，芳烷基，低级烷氧基，芳烷氧基或环烷基。 这些化合物是可用于例如治疗血栓形成疾病的心血管药。

    7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease
    9.
    发明授权
    7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease 失效
    7-氧杂双环庚烷取代的二酰胺及其可用于治疗血栓形成疾病的同种前列腺素类似物

    公开(公告)号：US4663336A

    公开(公告)日：1987-05-05

    申请号：US853788

    申请日：1986-04-18

    申请人： Masami Nakane ,  Joyce Reid

    发明人： Masami Nakane ,  Joyce Reid

    IPC分类号： A61K31/34 ,  A61K31/41 ,  A61K31/557 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P11/08 ,  A61P43/00 ,  C07D493/08

    CPC分类号： C07D493/08

    摘要： 7-Oxabicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, ##STR4## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

    摘要翻译： 提供7-氧杂双环庚烷取代的酰胺前列腺素类似物，其结构式为：其中m为0至4; A是-CH = CH-或-CH 2 -CH 2 - ; n为1至5; Q是-CH = CH-，-CH 2 - ，或单键; R为CO 2 H，CO 2烷基，CO 2碱金属，CO 2多羟基胺盐，-CH 2 OH，其中R 4和R 5相同或不同，为H，低级烷基，羟基，低级烷氧基或芳基，R 4和R 5中的至少一个为其它 羟基和低级烷氧基; p为1〜4; R1是H或低级烷基; q为1〜12; R2是H或低级烷基; R 3为H，低级烷基，低级烯基，低级炔基，芳基，芳基烷基，低级烷氧基，芳氧基，芳基烷氧基，氨基，烷基氨基芳基氨基，芳基烷基氨基，（其中n'为0,1或2 ），烷基氨基烷基，芳基氨基烷基，芳基烷基氨基烷基，烷氧基烷基，芳氧基烷基或芳基烷氧基烷基。 这些化合物是可用于例如治疗血栓形成疾病的心血管药。

    7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs
    10.
    发明授权
    7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs 失效
    7-氧杂双环庚烷取代的酰胺 - 硫代酰胺前列腺素类似物

    公开(公告)号：US4654355A

    公开(公告)日：1987-03-31

    申请号：US761261

    申请日：1985-08-01

    申请人： Masami Nakane ,  Joyce Reid

    发明人： Masami Nakane ,  Joyce Reid

    IPC分类号： A61K31/557 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P11/08 ,  C07D493/08 ,  A61K31/34 ,  A61K31/41 ,  C07D405/14

    CPC分类号： C07D493/08

    摘要： 7-Oxabicycloheptane substituted amide-thioamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy, amino, alkylamino, or arylamino.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

    摘要翻译： 提供7-氧杂双环庚烷取代的酰胺 - 硫代酰胺前列腺素类似物，其结构式为：其中m为0至4; A是-CH = CH-或-CH 2 CH 2 - ; n为1至5; Q是-CH = CH-，-CH 2 - ，或单键; R为CO 2 H，CO 2烷基，CO 2碱金属，CO 2多羟基胺盐，-CH 2 OH，其中R 4和R 5相同或不同，为H，低级烷基，羟基，低级烷氧基或芳基，R 4和R 5中的至少一个为其它 羟基和低级烷氧基; p为1〜4; R1是H或低级烷基; q为1〜12; R2是H或低级烷基; R 3为H，低级烷基，低级烯基，低级炔基，芳基，芳基烷基，低级烷氧基，芳烷氧基，氨基，烷基氨基或芳基氨基。 这些化合物是可用于例如治疗血栓形成疾病的心血管药。