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    Receptor blocker and vasodilator comprising indole derivative as active ingredient
    1.
    发明授权
    Receptor blocker and vasodilator comprising indole derivative as active ingredient 有权
    受体阻滞剂和包含吲哚衍生物作为活性成分的血管扩张剂

    公开(公告)号：US07872040B2

    公开(公告)日：2011-01-18

    申请号：US11663748

    申请日：2005-09-16

    申请人： Masanori Somei ,  Koki Shigenobu ,  Yoshio Tanaka

    发明人： Masanori Somei ,  Koki Shigenobu ,  Yoshio Tanaka

    IPC分类号： A61K31/405 ,  A61K31/40

    CPC分类号： A61K31/4045 ,  A61K31/405 ,  Y10S514/88 ,  Y10S514/929

    摘要： It is intended to find a compound that is structurally simpler than yohimbine, a pentacyclic condensed heterocyclic compound, and has an effect similar to that of yohimbine.The present invention relates to a pharmaceutical or food composition for α2 receptor blockage comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (wherein R1 represents a hydrogen, alkyl group, alkenyl group, alkynyl group, aromatic group, aralkyl group, acyl group, arylsulfonyl group, alkylsulfonyl group, or hydroxyl group; R2 represents a hydrocarbon group; R3, R4, R5, R6, and R7 are the same or different and represent a hydrogen, halogen, alkyl group, or alkoxy group; R8 represents a hydrogen or acyl group; n represents an integer of 1 to 6; and a and b are the same or different and represent 1 or 0).

    摘要翻译： 旨在找到结构上比育亨宾简单的化合物，五环稠合杂环化合物，并且具有与育亨宾相似的效果。 本发明涉及一种α2受体阻断剂的药物或食品组合物，其包含式（I）表示的化合物或其药学上可接受的盐：（其中R 1表示氢，烷基，烯基，炔基，芳族基团， 芳烷基，酰基，芳基磺酰基，烷基磺酰基或羟基; R 2表示烃基; R 3，R 4，R 5，R 6和R 7相同或不同，表示氢，卤素，烷基或烷氧基 ; R8表示氢或酰基; n表示1〜6的整数，a和b相同或不同，表示1或0）。

    Receptor Blocker and Vasodilator Comprising Indole Derivative as Active Ingredient
    2.
    发明申请
    Receptor Blocker and Vasodilator Comprising Indole Derivative as Active Ingredient 有权
    受体阻断剂和血管扩张剂包含吲哚衍生物作为活性成分

    公开(公告)号：US20090005430A1

    公开(公告)日：2009-01-01

    申请号：US11663748

    申请日：2005-09-16

    申请人： Masanori Somei ,  Koki Shigenobu ,  Yoshio Tanaka

    发明人： Masanori Somei ,  Koki Shigenobu ,  Yoshio Tanaka

    IPC分类号： A61K31/404 ,  A61P7/00

    CPC分类号： A61K31/4045 ,  A61K31/405 ,  Y10S514/88 ,  Y10S514/929

    摘要： It is intended to find a compound that is structurally simpler than yohimbine, a pentacyclic condensed heterocyclic compound, and has an effect similar to that of yohimbine.The present invention relates to a pharmaceutical or food composition for α2 receptor blockage comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (wherein R1 represents a hydrogen, alkyl group, alkenyl group, alkynyl group, aromatic group, aralkyl group, acyl group, arylsulfonyl group, alkylsulfonyl group, or hydroxyl group; R2 represents a hydrocarbon group; R3, R4, R5, R6, and R7 are the same or different and represent a hydrogen, halogen, alkyl group, or alkoxy group; R8 represents a hydrogen or acyl group; n represents an integer of 1 to 6; and a and b are the same or different and represent 1 or 0).

    摘要翻译： 旨在找到结构上比育亨宾简单的化合物，五环稠合杂环化合物，并且具有与育亨宾相似的效果。 本发明涉及用于α2受体阻断的药物或食品组合物，其包含由式（I）表示的化合物或其药学上可接受的盐：（其中R 1表示氢，烷基，烯基，炔基，芳族基团， 芳烷基，酰基，芳基磺酰基，烷基磺酰基或羟基; R 2表示烃基; R 3，R 4，R 5，R 6和R 7相同或不同，表示氢，卤素，烷基或烷氧基 ; R8表示氢或酰基; n表示1〜6的整数，a和b相同或不同，表示1或0）。