公开(公告)号：US20070054848A1

公开(公告)日：2007-03-08

申请号：US10551157

申请日：2004-03-26

申请人： Masaya Tohyama ,  Toshihide Yamashita ,  Hiroyuki Tanaka ,  Haruhisa Higuchi

发明人： Masaya Tohyama ,  Toshihide Yamashita ,  Hiroyuki Tanaka ,  Haruhisa Higuchi

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K39/395

CPC分类号： G01N33/6896 ,  A61K38/10 ,  A61K38/1709 ,  C07K16/2878

摘要： The present invention provides a pharmaceutical composition and method for regenerating nerves and treating neurological diseases based on nerve regeneration. The present invention employs a substance, such as Pep5, PKC, IP3, Rho, Rho GDI, Rho kinase, or the like, which are involved in a p75 signal transduction pathway, or an agent capable of specifically interacting with any of these substances to block or suppress the p75 signal transduction pathway, thereby stopping inhibition of nerve regeneration. As a result, nerve regeneration is resumed. The present invention is also the first to disclose that the PTD domain is useful as an agent for nerve regeneration.

摘要翻译： 本发明提供一种神经再生神经再生治疗神经系统疾病的药物组合物和方法。 本发明使用参与p75信号转导途径的物质，例如Pep5，PKC，IP3，Rho，Rho GDI，Rho激酶等物质，或能够与这些物质中的任何物质特异性相互作用的物质 阻断或抑制p75信号转导途径，从而阻止神经再生的抑制。 结果，恢复神经再生。 本发明也首先公开了PTD结构域可用作神经再生剂。