公开(公告)号：US09873668B2

公开(公告)日：2018-01-23

申请号：US15253504

申请日：2016-08-31

申请人： Mateon Therapeutics, Inc. ,  Baylor University

发明人： David J. Chaplin ,  Kishore Kumar Gaddale Devanna ,  Erica Parker ,  Kevin G. Pinney ,  Jiangli Song ,  Mary Lynn Trawick

IPC分类号： C07C337/08 ,  C07C49/786

CPC分类号： C07C337/08 ,  C07C49/786

摘要： This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

公开(公告)号：US08877967B2

公开(公告)日：2014-11-04

申请号：US13786142

申请日：2013-03-05

申请人： OXiGENE, Inc. ,  Baylor University

发明人： David J. Chaplin ,  Kishore Kumar Gaddale Devanna ,  Erica Parker ,  Kevin G. Pinney ,  Jiangli Song ,  Mary Lynn Trawick

IPC分类号： C07C337/08

CPC分类号： C07C337/08 ,  C07C49/786

摘要： This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

摘要翻译： 本发明涉及式I化合物和使用这些化合物治疗组织蛋白酶，特别是组织蛋白酶K或组织蛋白酶L的调节将在治疗上有用的条件的方法。

公开(公告)号：US09458103B2

公开(公告)日：2016-10-04

申请号：US14505165

申请日：2014-10-02

申请人： OXiGENE, Inc. ,  Baylor University

发明人： David J. Chaplin ,  Kishore Kumar Gaddale Devanna ,  Erica Parker ,  Kevin G. Pinney ,  Jiangli Song ,  Mary L. Trawick

IPC分类号： C07C337/08 ,  C07C49/786

CPC分类号： C07C337/08 ,  C07C49/786

摘要： This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

公开(公告)号：US20130296605A1

公开(公告)日：2013-11-07

申请号：US13786142

申请日：2013-03-05

申请人： OXIGENE, INC. ,  BAYLOR UNIVERSITY

发明人： David J. Chaplin ,  Kishore Kumar Gaddale Devanna ,  Erica Parker ,  Kevin G. Pinney ,  Jiangli Song ,  Mary L. Trawick

IPC分类号： C07C337/08

CPC分类号： C07C337/08 ,  C07C49/786

摘要： This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

公开(公告)号：US20150031915A1

公开(公告)日：2015-01-29

申请号：US14505165

申请日：2014-10-02

申请人： OXiGENE, Inc. ,  Baylor University

发明人： David J. Chaplin ,  Kishore Kumar Gaddale Devanna ,  Erica Parker ,  Kevin G. Pinney ,  Jiangli Song ,  Mary L. Trawick

IPC分类号： C07C337/08 ,  C07C49/786

CPC分类号： C07C337/08 ,  C07C49/786

摘要： This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

摘要翻译： 本发明涉及式I化合物和使用这些化合物治疗组织蛋白酶，特别是组织蛋白酶K或组织蛋白酶L的调节将在治疗上有用的条件的方法。