专利检索 ap:("Matthew Bernett" OR "John Desjarlais" OR "Suzanne Schubbert" OR "Christine Bonzon" OR "Rajat Varma" OR "Raphael Clynes") AND inv:"Suzanne Schubbert" 第 1 页

1.

发明申请
IL-7-FC-FUSION PROTEINS 有权

公开(公告)号：US20210070824A1

公开(公告)日：2021-03-11

申请号：US16875878

申请日：2020-05-15

申请人： Matthew Bernett , John Desjarlais , Suzanne Schubbert , Christine Bonzon , Rajat Varma , Raphael Clynes

发明人： Matthew Bernett , John Desjarlais , Suzanne Schubbert , Christine Bonzon , Rajat Varma , Raphael Clynes

IPC分类号： C07K14/54

摘要： Provided herein are dimeric IL-7-Fc fusion proteins that include Fc domains and one or more IL-7s. Also provided herein are variant IL-7s with modifications to reduce heterogeneity and/or reduced affinity/potency. Such variant IL-7s are useful, for example, in the subject dimeric IL-7-Fc fusion proteins. The dimeric IL-7-Fc fusion proteins can be used for applications where increased IL-7 activity is useful, for example, for increasing the proliferation of lymphocyte populations in mounting an anti-tumor response in a subject in need thereof.