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1.
公开(公告)号:US20110177027A1
公开(公告)日:2011-07-21
申请号:US13052496
申请日:2011-03-21
申请人: Matthias GRELL , Simon GOODMAN , Curzio RUEGG
发明人: Matthias GRELL , Simon GOODMAN , Curzio RUEGG
CPC分类号: A61K38/08 , A61K38/191 , A61K38/217 , A61K39/39541 , A61K2300/00
摘要: The invention relates to a combination therapy for the treatment of tumors metastases comprising administration of anti-angiogenic agents and tumor necrosis factor alpha (TNFa) optionally together with other cytotoxic agents, such as interferon gamma (IFNy) or chemotherapeutic agents such as anti-EGFR antibodies. The method and the pharmaceutical compositions comprising said agents can result in a synergistic potentiation of the tumor cell proliferation inhibition effect of each individual therapeutic agent, yielding more effective treatment than found by administering an individual component alone.
摘要翻译: 本发明涉及用于治疗肿瘤转移的组合疗法,包括任选地与其它细胞毒剂如干扰素γ(IFNγ)或化学治疗剂如抗EGFR一起施用抗血管生成剂和肿瘤坏死因子α(TNFa) 抗体。 包含所述试剂的方法和药物组合物可以导致每种单独治疗剂的肿瘤细胞增殖抑制作用的协同增强作用,产生比通过单独施用单独组分发现的更有效的治疗。