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1.发明授权Intermediate compounds for making dihydropteridinones useful as pharmaceutical compositions and processes of making the same 有权用作制备二氢蝶啶酮的中间体化合物可用作药物组合物及其制备方法公开(公告)号：US07750152B2
公开(公告)日：2010-07-06
申请号：US11941463
申请日：2007-11-16
申请人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Jurgen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Jurgen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： C07D475/00
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the pharmaceutical compositions, isomers, intermediates thereof and processes for preparing these dihydropteridinones. The compounds are useful the treatment and/or prevention of cancer, infections, inflammatory and autoimmune diseases.
摘要翻译： 公开了通式（I）的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，药物组合物，异构体，中间体和制备这些二氢蝶啶酮的方法。 该化合物可用于治疗和/或预防癌症，感染，炎症和自身免疫性疾病。
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2.发明申请Intermediate Compounds for making Dihydropteridinones Useful as Pharmaceutical Compositions 有权用作制备二氢蝶呤的中间体化合物可用作药物组合物公开(公告)号：US20080171747A1
公开(公告)日：2008-07-17
申请号：US11941463
申请日：2007-11-16
申请人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61K31/525 , C07D475/02
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求和说明书中给出的含义，其异构体，中间体和 制备这些二氢蝶啶酮的方法及其作为药物组合物的用途。
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3.发明申请Intermediate compounds for making dihydropteridinones useful as pharmaceutical compositions 审中-公开用作制备二氢蝶啶酮的中间体化合物，可用作药物组合物公开(公告)号：US20050014761A1
公开(公告)日：2005-01-20
申请号：US10909008
申请日：2004-07-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , A61K31/525 , C07D475/02
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶呤的中间体和方法及其用途 药物组合物。
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4.发明授权Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions 有权二氢蝶啶酮，其制备方法及其作为药物组合物的用途公开(公告)号：US06861422B2
公开(公告)日：2005-03-01
申请号：US10374876
申请日：2003-02-26
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , C07D487/04 , A61K31/4985
CPC分类号： C07D295/073 , C07D475/00
摘要： The present invention relates to new dihydropteridinones of general formula (I): wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新的二氢蝶啶酮：其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶的方法和用途 作为药物组合物。
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5.发明申请Methods of treating diseases or conditions using dihydropteridinone compounds 审中-公开使用二氢蝶啶酮化合物治疗疾病或病症的方法公开(公告)号：US20050014760A1
公开(公告)日：2005-01-20
申请号：US10903807
申请日：2004-07-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , A61K31/525
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶呤的中间体和方法及其用途 药物组合物。
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公开(公告)号：US20080293944A1
公开(公告)日：2008-11-27
申请号：US12129728
申请日：2008-05-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： C07D241/04
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的中间体和方法及其作为药物组合物的用途。
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7.发明授权Methods for treating diseases or conditions using dihydropteridinone compounds 有权使用二氢蝶啶酮化合物治疗疾病或病症的方法公开(公告)号：US07786299B2
公开(公告)日：2010-08-31
申请号：US11219945
申请日：2005-09-06
申请人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Jurgen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Jurgen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： C07D475/00 , C07D475/12 , C07D413/14
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的中间体和方法及其作为药物组合物的用途。
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公开(公告)号：US08003786B2
公开(公告)日：2011-08-23
申请号：US12873687
申请日：2010-09-01
申请人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky , Gisela Schnapp
发明人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky , Gisela Schnapp
IPC分类号： C07D475/00
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的中间体和方法及其作为药物组合物的用途。
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9.发明申请Methods for treating diseases or conditions using dihydropteridinone compounds 有权使用二氢蝶啶酮化合物治疗疾病或病症的方法公开(公告)号：US20060025411A1
公开(公告)日：2006-02-02
申请号：US11219945
申请日：2005-09-06
申请人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Martin Steegmaier , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61K31/5377 , C07D475/02 , A61K31/525
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求和说明书中给出的含义，其异构体，中间体和 制备这些二氢蝶啶酮的方法及其作为药物组合物的用途。
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10.发明申请New dihydropteridione derivatives, process for their manufacture and their use as medicament 有权新的二氢二萜衍生物，其制备方法及其作为药物的用途公开(公告)号：US20060052383A1
公开(公告)日：2006-03-09
申请号：US11210951
申请日：2005-08-24
申请人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Quant
发明人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Quant
IPC分类号： A61K31/525 , C07D475/02
CPC分类号： C07D487/04 , C07D475/00 , Y02P20/55
摘要： Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，
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