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公开(公告)号：US5695777A
公开(公告)日：1997-12-09
申请号：US241120
申请日：1994-05-10
IPC分类号： A61F13/02 , A61K31/727 , A61L15/60 , A61K9/70 , A61L15/00
CPC分类号： A61K31/727 , A61F13/023 , A61L15/60
摘要： A wound dressing for use with exuding wounds includes (a) an outer vapor permeable layer permitting transpiration of fluid from the dressing; (b) an intermediate layer of hydrogel adapted for absorbing wound exudate; (c) a wound-contacting layer for separating the intermediate hydrogel layer from the wound; (d) wicking means associated with the wound-contacting layer for conducting exudate from the wound to the hydrogel; and (e) a therapeutic agent retained in the dressing by the wound-contacting layer.
摘要翻译： 用于渗出伤口的伤口敷料包括（a）允许来自敷料的流体蒸发的外部透气层; （b）适于吸收伤口渗出物的水凝胶中间层; （c）用于将中间水凝胶层与伤口分离的伤口接触层; （d）与伤口接触层相关联的芯吸装置，用于将渗出物从伤口导入水凝胶; 和（e）通过伤口接触层保留在敷料中的治疗剂。
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2.发明授权Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs 失效疏水性压敏胶粘剂用于静脉注射药物的局部给药
公开(公告)号：US5173302A
公开(公告)日：1992-12-22
申请号：US590648
申请日：1990-09-28
CPC分类号： A61K9/7061 , A61L15/58
摘要： Novel hydrogel formulations useful as adhesive reservoirs for topical or transdermal drugs employ as the polymer base a crosslinked polymer or copolymer of 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof. The gels are prepared from polymerizable compositions comprising:20%-50% of a monofunctional monomer component, at least 75% of said component comprising 2-acrylamido-2-methylpropane sulfonic acid or a salt thereof, the balance being selected from the group consisting of acrylic acid, water soluble acrylic functional monomers and vinyl pyrrolidone;30%-50% of a glycol component selected from the group consisting of compounds of the formulaHO--(C.sub.2 H.sub.4 O).sub.n --H,HO--(C.sub.3 H.sub.6 O).sub.m --H and mixtures thereof, where n is in the range of about 4 to about 16 and m is 1-4;between about 0.02% and about 0.20% of a crosslinking monomer;an amount of a free radical polymerization initiator effective for initiating polymerization of said monofunctional monomer and crosslinking monomer components; anda therapeutically effective amount of a topically or transdermally deliverable drug, at least about 60% of said drug being dissolved in the formulation.
摘要翻译： 用作局部或透皮药物的粘合剂储存器的新型水凝胶制剂使用2-丙烯酰胺基-2-甲基丙磺酸或其盐的交联聚合物或共聚物作为聚合物基质。 凝胶由可聚合组合物制备，包括：20％-50％的单官能单体组分，至少75％的所述组分包含2-丙烯酰氨基-2-甲基丙磺酸或其盐，余量选自 的丙烯酸，水溶性丙烯酸官能单体和乙烯基吡咯烷酮; 30％-50％的选自式HO-（C 2 H 4 O）n H，HO-（C 3 H 6 O）m H的化合物及其混合物的二醇组分，其中n在约4至约16的范围内，m 是1-4; 约0.02％至约0.20％的交联单体; 一定量的自由基聚合引发剂，用于引发所述单官能单体和交联单体组分的聚合; 和治疗有效量的局部或透皮递送的药物，至少约60％的所述药物溶解在制剂中。
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公开(公告)号：US4605406A
公开(公告)日：1986-08-12
申请号：US637476
申请日：1984-08-03
CPC分类号： A61L27/56 , A61L27/18 , Y10S623/921
摘要： A method of fabricating prosthesis material having a conduit configuration.
摘要翻译： 一种制造具有导管结构的假体材料的方法。
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公开(公告)号：US4593053A
公开(公告)日：1986-06-03
申请号：US679653
申请日：1984-12-07
IPC分类号： A61K9/70 , A61L15/58 , C08L29/04 , C09J137/00 , C09J139/06 , A61K31/79
CPC分类号： A61K9/7053 , A61L15/585 , C09J139/06 , C08L29/04 , C09J2201/606 , Y10S514/944
摘要： Novel, hydrophilic, skin-compatible, pressure sensitive, solid, adhesive gel hydrogel composition comprising 25 to 50 weight percent polyvinyl pyrolidone (PVP) preferably having a molecular weight in the range of about 100,000 to 600,000, 2 to 5 weight percent polyvinyl alcohol (PVA) preferably having a molecular weight in the range of about 150,000 to 300,000, about 5 to about 40 weight percent humectant, about 3 to about 50 weight percent water, about 0 to about 50 weight percent of an ionic species. In a preferred aspect, the composition of the invention is utilized in an iontophoresis device to provide a hydrophilic gel matrix from which a drug is iontophoretically delivered.
摘要翻译： 新型的亲水性皮肤相容性的压敏粘合剂凝胶水凝胶组合物，其包含25至50重量％的聚乙烯基吡咯烷酮（PVP），优选具有约100,000至600,000的分子量，2至5重量％的聚乙烯醇（ PVA），优选分子量为约150,000至300,000，约5至约40重量％的湿润剂，约3至约50重量％的水，约0至约50重量％的离子物质。 在优选的方面，本发明的组合物用于离子电渗装置中以提供离子电渗传递药物的亲水性凝胶基质。
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