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1.发明授权Seco-d steroids active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them 失效对心血管系统活化的半胱固醇类固醇，其制备方法和含有它们的药物组合物
公开(公告)号：US5955632A
公开(公告)日：1999-09-21
申请号：US891033
申请日：1997-07-10
申请人： Mauro Gobbini , Sergio De Munari , Giorgio Fedrizzi , Patrizia Ferrari , Piero Melloni , Marco Santagostino , Marco Torri
发明人： Mauro Gobbini , Sergio De Munari , Giorgio Fedrizzi , Patrizia Ferrari , Piero Melloni , Marco Santagostino , Marco Torri
IPC分类号： A61K31/045 , A61K31/13 , A61K31/155 , A61P9/00 , A61P9/12 , C07C251/38 , C07C251/58 , C07C281/18 , C07D295/04 , A61K31/495 , C07C291/00 , C07D211/06
CPC分类号： C07C281/18 , C07C251/58 , C07C2103/26
摘要： New seco-D steroid derivatives, processes for their preparation and pharmaceutical compositions are provided, which are active on the cardiovascular system. The seco-D steroid derivatives have the following general formula (I): ##STR1##
摘要翻译： 提供新的seco-D类固醇衍生物，其制备方法和药物组合物，其在心血管系统上具有活性。 次级D类固醇衍生物具有以下通式（I）：
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2.发明申请AMINOOXIME DERIVATIVES OF 2- AND/OR 4-SUBSTITUTED ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 失效2-和/或4-取代的安慰剂和安慰剂作为心血管疾病药物的氨基酸衍生物公开(公告)号：US20100324003A1
公开(公告)日：2010-12-23
申请号：US12680988
申请日：2008-09-18
申请人： Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Giuseppe Marazzi , Marco Torri , Walter Cabri
发明人： Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Giuseppe Marazzi , Marco Torri , Walter Cabri
IPC分类号： A61K31/58 , C07J41/00 , C07J43/00 , C07J71/00 , C07J53/00 , A61K31/5685 , A61P9/12 , A61P9/00
CPC分类号： C07J41/0016 , C07J43/003
摘要： New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
摘要翻译： 2-和/或4-取代的雄甾烷和雄甾烯-3的位置3上的新的氨基肟衍生物，其制备方法以及含有它们用于治疗心力衰竭和高血压的心血管疾病的药物组合物。 特别地描述了具有通式（I）的化合物，其中基团具有本申请中详细描述的含义。
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3.发明授权Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders 失效作为心血管疾病药物的2-和/或4-取代的雄甾烷和雄激素的氨基肟衍生物公开(公告)号：US08664210B2
公开(公告)日：2014-03-04
申请号：US12680988
申请日：2008-09-18
申请人： Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Marco Torri , Giuseppe Marazzi , Walter Cabri
发明人： Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Marco Torri , Giuseppe Marazzi , Walter Cabri
CPC分类号： C07J41/0016 , C07J43/003
摘要： New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
摘要翻译： 2-和/或4-取代的雄甾烷和雄甾烯-3的位置3上的新的氨基肟衍生物，其制备方法以及含有它们用于治疗心力衰竭和高血压的心血管疾病的药物组合物。 特别地描述了具有通式（I）的化合物，其中基团具有本申请中详细描述的含义。
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4.发明申请AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 有权安非他酮和安慰剂作为心血管疾病药物的偶氮胆碱衍生物公开(公告)号：US20090275542A1
公开(公告)日：2009-11-05
申请号：US12296532
申请日：2007-04-11
申请人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
发明人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
CPC分类号： C07J43/003
摘要： Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
摘要翻译： 式（I）化合物其中：所述基团如说明书中所定义，可用于制备用于治疗心血管疾病，特别是心力衰竭和高血压的药物。 这些化合物是Na +，K + -ATP酶的酶活性的抑制剂。 它们可用于制备用于治疗由内源性哇巴因的高血压作用引起的疾病的药物，例如常染色体显性多囊肾病（ADPKD）的肾衰竭进展，先兆子痫高血压和蛋白尿以及肾衰竭进展 adducin多态性。
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5.发明授权Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders 有权雄激素和雄激素的氮杂环基衍生物作为心血管疾病的药物公开(公告)号：US08536160B2
公开(公告)日：2013-09-17
申请号：US12296532
申请日：2007-04-11
申请人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
发明人： Alberto Cerri , Giorgio Fedrizzi , Alessandra Benicchio , Giuseppe Bianchi , Patrizia Ferrari , Mauro Gobbini , Rosamaria Micheletti , Marco Pozzi , Piero Enrico Scotti
CPC分类号： C07J43/003
摘要： Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
摘要翻译： 式（I）化合物其中：所述基团如说明书中所定义，可用于制备用于治疗心血管疾病，特别是心力衰竭和高血压的药物。 这些化合物是Na +，K + -ATP酶的酶活性的抑制剂。 它们可用于制备用于治疗由内源性哇巴因的高血压作用引起的疾病的药物，例如常染色体显性多囊肾病（ADPKD）的肾衰竭进展，先兆子痫高血压和蛋白尿和肾衰竭进展 adducin多态性。
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