公开(公告)号：US11034993B2

公开(公告)日：2021-06-15

申请号：US16266427

申请日：2019-02-04

Applicant: McMaster University

Inventor： Paul Y. Kim ,  Chengliang Wu

IPC: C12Q1/56 ,  A61P7/02 ,  G01N33/86 ,  G01N33/68

Abstract: The present disclosure relates to an assay that measures the level of factor Xa inhibitors in a sample by detecting residual factor Xa activity. In particular, the assay utilizes a mutant variant of prothrombin that lacks proteolytic activity; a prothrombinase complex mixture; and a thrombin-specific inhibitor and measures the factor Xa activity.

公开(公告)号：US20190241931A1

公开(公告)日：2019-08-08

申请号：US16266427

申请日：2019-02-04

Applicant: McMaster University

Inventor： Paul Y. Kim ,  Chengliang Wu

IPC: C12Q1/56

CPC classification number: C12Q1/56 ,  G01N2333/96444

Abstract: The present disclosure relates to an assay that measures the level of factor Xa inhibitors in a sample by detecting residual factor Xa activity. In particular, the assay utilizes a mutant variant of prothrombin that lacks proteolytic activity; a prothrombinase complex mixture; and a thrombin-specific inhibitor and measures the factor Xa activity.