公开(公告)号：US20200308278A1

公开(公告)日：2020-10-01

申请号：US16904451

申请日：2020-06-17

Applicant: McMaster University

Inventor： Jonathan Lorne BRAMSON ,  Christopher W. HELSEN ,  Joanne Alicia HAMMILL ,  Kenneth Anthony MWAWASI

IPC: C07K16/28 ,  C07K14/73

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

公开(公告)号：US20200239571A1

公开(公告)日：2020-07-30

申请号：US16826053

申请日：2020-03-20

Applicant: McMaster University

Inventor： Jonathan Lorne BRAMSON ,  Christopher W. HELSEN ,  Joanne Alicia HAMMILL ,  Kenneth Anthony MWAWASI

IPC: C07K16/28 ,  C07K14/73

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

公开(公告)号：US20210130435A1

公开(公告)日：2021-05-06

申请号：US17248174

申请日：2021-01-12

Applicant: McMaster University

Inventor： Jonathan BRAMSON ,  Christopher W. HELSEN ,  Galina DENISOVA ,  Rajanish GIRI ,  Kenneth MWAWASI

IPC: C07K14/73 ,  A61K35/17 ,  C07K16/28 ,  C07K14/725 ,  C07K16/32

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

公开(公告)号：US20200071377A1

公开(公告)日：2020-03-05

申请号：US16547421

申请日：2019-08-21

Applicant: McMaster University

Inventor： Jonathan BRAMSON ,  Christopher W. HELSEN ,  Galina DENISOVA ,  Rajanish GIRI ,  Kenneth MWAWASI

IPC: C07K14/73 ,  C07K16/28 ,  A61K35/17 ,  C07K16/32 ,  C07K14/725

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

公开(公告)号：US20200270330A1

公开(公告)日：2020-08-27

申请号：US15929510

申请日：2020-05-06

Applicant: McMaster University

Inventor： Jonathan BRAMSON ,  Christopher W. HELSEN ,  Galina DENISOVA ,  Rajanish GIRI ,  Kenneth MWAWASI

IPC: C07K14/73 ,  A61K35/17 ,  C07K16/28 ,  C07K14/725 ,  C07K16/32

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

公开(公告)号：US20200261500A1

公开(公告)日：2020-08-20

申请号：US15929513

申请日：2020-05-06

Applicant: Triumvira Immunologics USA, Inc. ,  McMaster University

Inventor： Jonathan Lorne BRAMSON ,  Christopher W. HELSEN ,  Joanne Alicia HAMMILL ,  Kenneth Anthony MWAWASI

IPC: A61K35/17 ,  C07K14/82 ,  A61P35/00 ,  C07K14/725

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

公开(公告)号：US20200024345A1

公开(公告)日：2020-01-23

申请号：US16442274

申请日：2019-06-14

Applicant: McMaster University

Inventor： Jonathan Lorne BRAMSON ,  Christopher W. HELSEN ,  Joanne Alicia HAMMILL ,  Kenneth Anthony MWAWASI

IPC: C07K16/28 ,  C07K14/73

Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.