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公开(公告)号：US20220331364A1
公开(公告)日：2022-10-20
申请号：US17810238
申请日：2022-06-30
Applicant: Triumvira Immunologics USA, Inc. , McMaster University
Inventor： Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
IPC: A61K35/17 , C07K14/725 , A61P35/00 , C07K14/82
Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
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公开(公告)号：US11878035B2
公开(公告)日：2024-01-23
申请号：US18188326
申请日：2023-03-22
Applicant: Triumvira Immunologics USA, Inc. , McMaster University
Inventor： Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
IPC: A61K48/00 , A61K35/17 , C07K14/725 , A61P35/00 , C07K14/82 , C07K14/73 , C07K14/705 , C07K16/28 , C07K16/32
CPC classification number: A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70514 , C07K14/70517 , C07K14/82 , C07K16/2803 , C07K16/2809 , C07K16/32 , C07K2317/622 , C07K2319/03
Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
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公开(公告)号：US11406667B2
公开(公告)日：2022-08-09
申请号：US17394280
申请日：2021-08-04
Applicant: Triumvira Immunologies USA, Inc. , McMaster University
Inventor： Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
IPC: C07K14/73 , A61K35/17 , C07K14/725 , A61P35/00 , C07K14/82
Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
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公开(公告)号：US20230210905A1
公开(公告)日：2023-07-06
申请号：US18188326
申请日：2023-03-22
Applicant: Triumvira Immunologics USA, Inc. , McMaster University
Inventor： Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
IPC: C07K16/32 , C07K14/725 , A61K35/17 , C07K14/705 , C07K16/28 , C07K14/73 , A61P35/00
CPC classification number: C07K16/32 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70514 , C07K14/70517 , C07K16/2803 , C07K16/2809 , C07K2317/622 , C07K2319/03
Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
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公开(公告)号：US11111298B2
公开(公告)日：2021-09-07
申请号：US16904451
申请日：2020-06-17
Applicant: McMaster University
Inventor： Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
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Patent Agency Ranking
公开(公告)号：US11110123B2
公开(公告)日：2021-09-07
申请号：US15929513
申请日：2020-05-06
Applicant: Triumvira Immunologics USA, Inc. , McMaster University
Inventor： Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
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公开(公告)号：US11976117B2
公开(公告)日：2024-05-07
申请号：US16826053
申请日：2020-03-20
Applicant: McMaster University
Inventor： Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
CPC classification number: C07K16/2803 , C07K14/70514 , C07K16/2809 , C07K2317/622 , C07K2319/03
Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
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公开(公告)号：US20240016841A1
公开(公告)日：2024-01-18
申请号：US18251992
申请日：2021-11-05
Applicant: Triumvira Immunologics USA, Inc. , McMaster University
Inventor： Jonathan Lorne Bramson , SeungMi Yoo , Sarah Asbury , Allyson Moore , Ling Wang , Brian Philip
CPC classification number: A61K35/17 , A61K31/675 , C07K16/2803 , C07K16/32 , C07K16/2878 , A61K39/4611 , A61K39/464406 , A61K39/464412 , A61K38/2013 , A61P35/00 , A61K2239/13 , A61K2239/21
Abstract: γδ T cells comprising a molecule comprising (i) a target-specific antigen-binding domain, (ii) an antigen-binding domain that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide are provided.
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公开(公告)号：US11453723B1
公开(公告)日：2022-09-27
申请号：US17304924
申请日：2021-06-28
Applicant: McMaster University
Inventor： Jonathan Lorne Bramson , Joanne Alicia Hammill , Christopher W. Helsen
Abstract: BCMA T cell antigen coupler (TAC) polypeptides having (i) an antigen-binding domain that binds BCMA, (ii) an antigen-binding domain that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide are provided.
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公开(公告)号：US20210369780A1
公开(公告)日：2021-12-02
申请号：US17394280
申请日：2021-08-04
Applicant: Triumvira Immunologics USA, Inc. , McMaster University
Inventor： Jonathan Lorne Bramson , Christopher W. Helsen , Joanne Alicia Hammill , Kenneth Anthony Mwawasi
IPC: A61K35/17 , C07K14/725 , A61P35/00 , C07K14/82
Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
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