公开(公告)号：US20250099058A1

公开(公告)日：2025-03-27

申请号：US18730936

申请日：2023-01-20

Applicant: McMaster University

Inventor： Zahra Keshavarz Motamed ,  Mohamed Abdelkhalek

IPC: A61B6/50 ,  A61B6/00 ,  A61B6/03 ,  G06T5/20 ,  G06T5/70 ,  G06T7/00 ,  G06T7/11 ,  G06T7/62 ,  G06T7/66 ,  G16H30/40

Abstract: Described is a method for assessing aortic valve calcification using contrast-enhanced CT. The method comprises: receiving CT images of the aortic valve; pre-processing received images to have a field of view focused on an aortic root corresponding to the aortic valve; implementing a fast-marching method for the pre-processed images to segment the aortic valve from surrounding tissue to generate an aortic root model; determining multiple principal axes and multiple landmark points based on the pre-processed images and the aortic root model to define a local coordinate system relative to leaflets of the aortic valve; generating a calcification model based on the pre-processed images and aortic root model by iteratively changing an initial estimate of calcific HU threshold until a minimum false positive rate FPR criterion is reached; and generating an indicator quantifying calcification of the aortic valve based on the calcification model, the principal axes and the landmark points.