公开(公告)号：US11845791B2

公开(公告)日：2023-12-19

申请号：US17653681

申请日：2022-03-07

申请人： MedImmune, LLC

发明人： Claire Dobson ,  Fiona Cusdin ,  Darren Schofield ,  Peter Cariuk ,  Elaine Hurt ,  Margareta Ek ,  Carina Johansson ,  Jenny Sandmark

IPC分类号： C07K16/22 ,  A61P35/00 ,  A61P21/00 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61P21/00 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92

摘要： The present disclosure is directed to human GDF-15-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect human GDF-15 and/or in methods of treating cancer or body weight loss, including cachexia, associated with over-expression of human GDF-15.