公开(公告)号：US20020043267A1

公开(公告)日：2002-04-18

申请号：US09919879

申请日：2001-08-02

Applicant: Medi-Physics Inc.

Inventor： Norbert Weiler ,  Balthasar Eberle ,  Wolfgang Schreiber ,  Klaus Markstaller ,  Hans-Ulrich Kauczor ,  Timothy P.L. Roberts ,  Werner Heil ,  Reinhard Surkau ,  Anselm Deninger ,  Lars Lauer ,  Tino Grossmann ,  Michael Ebert

IPC: A61B005/05 ,  A61B019/00

CPC classification number: G01R33/5601

Abstract: The invention provides a method of detecting regional variations in oxygen uptake from the lungs of an air-breathing animal subject, said method comprising administering into the lungs of said subject a diagnostically effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, detecting the magnetic resonance signal from said agent in said lungs, determining the temporal variation in relaxation rate for said signal for at least one region of interest within said lungs, and from said variation generating a qualitative or quantitative value or image indicative of the oxygen uptake from the alveolar space in said at least one region of interest.

Abstract translation: 本发明提供一种检测来自空气呼吸动物受试者的肺的氧摄取的区域变化的方法，所述方法包括向所述受试者的肺施用诊断有效量的气体超极化磁共振成像剂，检测磁共振 来自所述肺中的所述药剂的信号，确定所述肺内至少一个感兴趣区域的所述信号的松弛率的时间变化，并且根据所述变化产生指示来自肺泡空间的氧吸收的定性或定量值或图像 在所述至少一个感兴趣的区域中。