公开(公告)号：US10940113B2

公开(公告)日：2021-03-09

申请号：US15901968

申请日：2018-02-22

Applicant: Medical And Pharmaceutical Industry Technology And Development Center

Inventor： Chih-Chiang Yang ,  Wen-Che Wang ,  Chiao-Ling Hsu

IPC: A61K9/20 ,  A61K9/28 ,  A61K31/196 ,  A61K31/606

Abstract: A pharmaceutical composition for colon targeting, a method for treating a colon-related disease using the same and a preparation method thereof are disclosed. The pharmaceutical composition of the present disclosure comprises: a core matrix comprising a cross-linked hydrogel and an active ingredient, wherein the active ingredient is dispersed in the cross-linked hydrogel, and a content of the active ingredient is 65 wt % to 95 wt % based on a total weight of the core matrix.

公开(公告)号：US11752104B2

公开(公告)日：2023-09-12

申请号：US16887259

申请日：2020-05-29

Applicant: MEDICAL AND PHARMACEUTICAL INDUSTRY TECHNOLOGY AND DEVELOPMENT CENTER

Inventor： Meng-Kun Tsai ,  Chih-Chiang Yang ,  Wen-Che Wang ,  Tzu-Yu Chien ,  Chien-Chia Wu ,  Lai-Cheng Chin

IPC: A61K9/16 ,  A61K31/717 ,  A61K31/436 ,  A61K9/00

CPC classification number: A61K9/167 ,  A61K9/0053 ,  A61K31/436 ,  A61K31/717

Abstract: An oral composition includes an immediate-release pharmaceutical admixture and an extended-release pharmaceutical admixture. The immediate-release pharmaceutical admixture includes a first portion of an active ingredient and a first portion of a hydrophilic dispersant, in which the active ingredient is substantially insoluble in water. The extended-release pharmaceutical admixture includes a controlled-release material, a second portion of the active ingredient, and a second portion of the hydrophilic dispersant, wherein the second portion of the active ingredient and the second portion of the hydrophilic dispersant are mixed in the controlled-release material, wherein the active ingredient is present as a nanoparticle in the immediate-release pharmaceutical admixture and the extended-release pharmaceutical admixture.