公开(公告)号：US09220775B2

公开(公告)日：2015-12-29

申请号：US14359864

申请日：2012-11-20

申请人： Medlmmune LLC

发明人： Partha S. Chowdhury ,  David Tice ,  Zhan Xiao ,  Philipp Steiner ,  Krista Kinneer ,  Marlon Rebelatto

IPC分类号： C07K16/32 ,  A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  G01N33/574 ,  A61K39/00

CPC分类号： C07K16/2863 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3069 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57492 ,  A61K2300/00

摘要： The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.

摘要翻译： 本发明涉及结合HER3受体的细胞外结构域的抗体及其抗原结合片段，并通过配体依赖性和/或配体非依赖性机制抑制各种HER3受体相关功能。 还提供了具有增加的半衰期的组合物。 此外，本发明提供用于诊断和治疗与HER3介导的信号转导相关的疾病的组合物和方法。

公开(公告)号：US11091554B2

公开(公告)日：2021-08-17

申请号：US16024391

申请日：2018-06-29

申请人： Medlmmune, LLC

发明人： Partha S. Chowdhury ,  David Tice ,  Zhan Xiao ,  Philipp Steiner ,  Krista Kinneer ,  Marlon Rebelatto

IPC分类号： C07K16/28 ,  C07K16/32 ,  A61K39/395 ,  A61K45/06 ,  G01N33/574 ,  C07K16/30 ,  C07K16/40 ,  A61K39/00

摘要： The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.