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公开(公告)号:US20130045948A1
公开(公告)日:2013-02-21
申请号:US13515010
申请日:2010-12-10
申请人: Mei H. Dung , Robert James Pasteris
发明人: Mei H. Dung , Robert James Pasteris
IPC分类号: A61K31/454 , C07F7/10 , A61K31/695 , A61K31/4545 , A61P25/24 , A61K31/496 , A61P25/00 , A61P29/00 , A61P25/22 , C07D417/14 , A61K31/506
CPC分类号: C07D417/14
摘要: Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein A, W, X, G, R1, R2, R3, R4, m and n are as defined in the disclosure. Also disclosed are pharmaceutical compositions containing the compounds of Formula 1 and methods for treating a disease or condition mediated by fatty acid amide hydrolase activity comprising applying a therapeutically effective amount of a compound or a composition of the invention.
摘要翻译: 公开了式1的化合物,包括所有立体异构体,N-氧化物及其盐,其中A,W,X,G,R 1,R 2,R 3,R 4,m和n如本公开所定义。 还公开了含有式1化合物的药物组合物和用于治疗由脂肪酸酰胺水解酶活性介导的疾病或病症的方法,包括施用治疗有效量的本发明化合物或组合物。