公开(公告)号：US20240025922A1

公开(公告)日：2024-01-25

申请号：US18313652

申请日：2023-05-08

申请人： Merck Patent GmbH

发明人： Momar TOURE ,  Bin LI ,  Constantin NEAGU ,  Yanping WANG ,  Theresa JOHNSON ,  Andrea UNZUE LOPEZ ,  Yufang XIAO ,  Emily FRIIS ,  Maria DIPOTO ,  Satenig GULER

IPC分类号： C07D519/00

CPC分类号： C07D519/00

摘要： Tetrahydropyrido[3,4-d]pyrimidines compounds are provided that are potent HPK1 inhibitors. The compounds are useful to treat or prevent cancer and/or inflammatory and/or autoimmune diseases or symptoms thereof in mammals, particularly humans. The compounds have a chemical structure of the general Formula (I), (II), (III), (IV) or (V) or enantiomers or diastereomers or mixtures thereof or pharmaceutically acceptable salts thereof.