专利检索 ap:("Merck Sharp & Dohme B.V.") AND inv:"Hans C. Raaijmakers" 第 1 页

1.

发明授权
4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as BtK inhibitors 有权

公开(公告)号：US09790226B2

公开(公告)日：2017-10-17

申请号：US15019561

申请日：2016-02-09

申请人： Merck Sharp & Dohme B.V.

发明人： Tjeerd A. Barf , Christiaan Gerardus Johannes Maria Jans , Adrianus Petrus Antonius de Man , Arthur A. Oubrie , Hans C. Raaijmakers , Johannes Bernardus Maria Rewinkel , Jan Gerard Sterrenburg , Jacobus C. H. M. Wijkmans

IPC分类号： C07D487/04 , A61K31/4985 , C07D519/00 , A61K31/501 , A61K31/506 , A61K31/55 , A61K31/5377

CPC分类号： C07D487/04 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/55 , C07D519/00 , Y02A50/411

摘要： The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.