公开(公告)号：US20220034902A1

公开(公告)日：2022-02-03

申请号：US17299559

申请日：2019-12-06

申请人： Eberhard DURR ,  Yaping LIU ,  Zhifeng CHEN ,  Arthur FRIDMAN ,  Merck Sharp & Dohme Corp.

发明人： Eberhard Durr ,  Yaping Liu ,  Zhifeng Chen ,  Arthur Fridman

IPC分类号： G01N33/68 ,  C07K16/12

摘要： A method is described for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of antibody producing cell libraries such as B-cell and hybridoma libraries. Specifically, the method relates to application of reversed immunocapture and high resolution tandem mass spectrometry for the identification of heavy and light chain pairs of binding antibodies obtained from high throughput screens of antibody producing cell libraries.

公开(公告)号：US11566051B2

公开(公告)日：2023-01-31

申请号：US16964118

申请日：2019-01-24

申请人： Merck Sharp & Dohme Corp. ,  Lan Zhang ,  Arthur Fridman ,  Eberhard Durr ,  Andrew Bett

发明人： Lan Zhang ,  Arthur Fridman ,  Eberhard Durr ,  Andrew Bett

IPC分类号： C07K14/135 ,  A61K39/155 ,  C12N7/00 ,  A61K39/00

摘要： The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions comprising the RSV F proteins.

公开(公告)号：US20210300971A1

公开(公告)日：2021-09-30

申请号：US16964118

申请日：2019-01-24

申请人： Merck Sharp & Dohme Corp.

发明人： Lan Zhang ,  Arthur Fridman ,  Eberhard Durr ,  Andrew Bett

IPC分类号： C07K14/135 ,  A61K39/155 ,  C12N7/00

摘要： The disclosure relates to stable RSV F proteins and immunogenic compositions containing the same, as well as methods of using the immunogenic compositions and compositions comprising the RSV F proteins.