专利检索 ap:("Merck Sharp & Dohme Corp.") AND inv:"Elaine M Pinheiro" 第 1 页

1.

发明授权
Compositions and methods for treating cancer with a combination of programmed death receptor (PD-1) antibodies and a CXCR2 antagonist 有权

公开(公告)号：US11052065B2

公开(公告)日：2021-07-06

申请号：US16649756

申请日：2018-09-24

申请人： Merck Sharp & Dohme Corp.

发明人： Elaine M Pinheiro , Michael Rosenzweig , Robert A. Kastelein , David R. Kaufman , Deborah A. Law

IPC分类号： A61K31/341 , C07K16/28 , A61P35/04 , A61K39/00

摘要： The present invention relates to methods of treating a cell proliferation disorder (e.g., cancer) comprising administering: (a) a compound having the Formula (I), wherein R1 or R2 are as herein defined, or a pharmaceutically acceptable salt thereof; and (b) an anti-human PD-1 antibody or antigen binding fragment thereof to a human patient in need thereof. Also disclosed are therapeutic combinations and kits containing such agents for the treatment of cancers.

2.

发明申请
COMPOSITIONS AND METHODS FOR TREATING CANCER WITH A COMBINATION OF PROGRAMMED DEATH RECEPTOR (PD-1) ANTIBODIES AND A CXCR2 ANTAGONIST 审中-公开

公开(公告)号：US20200276153A1

公开(公告)日：2020-09-03

申请号：US16649756

申请日：2018-09-24

申请人： Merck Sharp & Dohme Corp.

发明人： Elaine M Pinheiro , Michael Rosenzweig , Robert A. Kastelein , David R. Kaufman , Deborah A. Law

IPC分类号： A61K31/341 , C07K16/28 , A61P35/04

摘要： The present invention relates to methods of treating a cell proliferation disorder (e.g., cancer) comprising administering: (a) a compound having the Formula (I), wherein R1 or R2 are as herein defined, or a pharmaceutically acceptable salt thereof; and (b) an anti-human PD-1 antibody or antigen binding fragment thereof to a human patient in need thereof. Also disclosed are therapeutic combinations and kits containing such agents for the treatment of cancers.