公开(公告)号：US20220119351A1

公开(公告)日：2022-04-21

申请号：US17606154

申请日：2020-04-27

申请人： Merck Sharp & Dohme Corp.

发明人： Ian M. Bell ,  Brian T. Campbell ,  Brendan M. Crowley ,  James Fells ,  Kenneth J. Leavitt ,  Anthony J. Roecker ,  Andrew John Harvey ,  Belinda C. Huff ,  Dharam Paul ,  Christophe Morice ,  Christophe Joseph ,  Patrick Bazzini ,  Jean-Marie Contreras ,  Fabrice Garrido ,  Aurelie Witzel

IPC分类号： C07D221/20 ,  C07D401/12 ,  A61K45/06 ,  A61K31/444 ,  A61K31/438 ,  C07D413/12 ,  C07D401/14

摘要： The present disclosure relates to compounds of formula (I) that are useful as modulators of 7α nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.