公开(公告)号：US20220250013A1

公开(公告)日：2022-08-11

申请号：US17618641

申请日：2020-06-15

申请人： Merck Sharp & Dohme Corp.

发明人： John H. Roosa ,  Alan S. D'Alessandro ,  Robert O'Connor ,  Luke Schenck ,  Timothy Stanoch

IPC分类号： B01F21/10 ,  B01F35/71 ,  B01F35/75

摘要： A solids charging containment apparatus and method for mixing a solvent with a dry powder, comprising a dual compartment isolator for safely removing the dry powder from a dry powder container, a mixing vessel, and a negative cascading pressure controller. The dual compartment isolator comprises a staging compartment, a charging compartment and a raw material entry port, which is connected to the staging compartment and configured to isolate the dry powder container from the surrounding atmosphere. The mixing vessel includes a mixing chamber and a solids charging port fluidly connecting the mixing chamber to a containment valve in the charging compartment of the dual compartment isolator. The negative cascading pressure controller generates negative pressure in both the staging compartment and the charging compartment. The containment apparatus and method may be used to produce a slurry or solution mixture of solvent and dry powder during drug processing.