公开(公告)号：US10646494B2

公开(公告)日：2020-05-12

申请号：US16326039

申请日：2017-08-14

Applicant: Merck Sharp & Dohme Corp.

Inventor： Wensheng Yu ,  Ling Tong ,  Joseph A. Kozlowski ,  Craig A. Coburn ,  De-Yi Yang ,  Deyou Sha ,  Jae-Hun Kim ,  Michael Dwyer ,  Kartik M Keertikar ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang

IPC: C07D498/04 ,  A61K31/5365 ,  C07D519/00 ,  C07D513/04 ,  A61K45/06 ,  A61P31/12 ,  A61P31/22 ,  A61P31/14 ,  A61K31/4995

Abstract: The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.