公开(公告)号：US20190269679A1

公开(公告)日：2019-09-05

申请号：US16462344

申请日：2017-12-11

申请人： Merck Sharp & Dohme Corp.

发明人： John S. Debenham ,  Jason M. Cox ,  Ping Lan ,  Zhongxiang Sun ,  Zhe Feng ,  Chunrui Sun ,  Michael W. Seganish ,  Zhong Lai ,  Cheng Zhu ,  Thomas Bara ,  Murali Rajagopalan ,  Qun Dang ,  Hyunjin M. Kim ,  Bin Hu ,  Jinglai Hao

IPC分类号： A61K31/497 ,  A61K31/4439 ,  A61K31/42 ,  A61K31/444 ,  C07D417/14 ,  C07D413/04 ,  C07D413/14 ,  C07D231/20

摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.