公开(公告)号：US09096598B2

公开(公告)日：2015-08-04

申请号：US14349377

申请日：2012-09-28

Applicant: Merck Sharp & Dohme Corp.

Inventor： John W. Butcher ,  David Witter ,  Christopher Dinsmore ,  June Kim ,  John Hendrix ,  Raksha Archarya ,  Sean P. Ahearn ,  Joon Jung ,  Alexey Rivkin ,  Philip Jones

IPC: C07D401/10 ,  A61K31/437 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract translation: 本发明提供了作为JAK抑制剂的式I化合物，因此可用于治疗JAK介导的疾病如类风湿性关节炎，哮喘，COPD和癌症。