专利检索 ap:("Merck Sharp & Dohme Corp.") AND inv:"Zachary E. Dance" 第 1 页

1.

发明申请
NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE 有权

公开(公告)号：US20170233383A1

公开(公告)日：2017-08-17

申请号：US15514584

申请日：2015-09-25

申请人： Zachary E. DANCE , Scott TRZASKA , Yong LIU , Richard John VARSOLONA , Gregory YORK , Merck Sharp & Dohme Corp.

发明人： Scott Trzaska , Zachary E. Dance , Yong Liu , Richard John Varsolona , Gregory York

IPC分类号： C07D417/12 , C07C309/30

CPC分类号： C07D417/12 , C07B2200/13 , C07C309/30

摘要： The present invention provides four crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.

2.

发明授权
Crystalline forms of a BACE inhibitor, compositions, and their use 有权

公开(公告)号：US10017505B2

公开(公告)日：2018-07-10

申请号：US15514584

申请日：2015-09-25

申请人： Merck Sharp & Dohme Corp.

发明人： Scott Trzaska , Zachary E. Dance , Yong Liu , Richard John Varsolona , Gregory York

IPC分类号： C07D417/12 , C07C309/30

CPC分类号： C07D417/12 , C07B2200/13 , C07C309/30

摘要： The present invention provides four crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.