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公开(公告)号:US11530250B2
公开(公告)日:2022-12-20
申请号:US16980579
申请日:2019-03-18
申请人: Merck Sharp & Dohme Corp. , Ahmet Kekec , Nancy Jo Kevin , Bing Li , Songnian Lin , Craig A. Parish , Weijuan Tang
发明人: Ahmet Kekec , Nancy Jo Kevin , Bing Li , Songnian Lin , Craig A. Parish , Weijuan Tang
摘要: The present invention relates to tyrosine-specific functionalized insulin analogs and processes of making such tyrosine-specific functionalized insulin analogs using R-3H-1,2,4-triazoline-3,5-(4H)diones (PTAD).
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公开(公告)号:US20210002345A1
公开(公告)日:2021-01-07
申请号:US16980579
申请日:2019-03-18
申请人: Ahmet KEKEC , Nancy Jo KEVIN , Bing LI , Songnian LIN , Craig A. PARISH , Weijuan TANG , Merck Sharp & Dohme Corp.
发明人: Ahmet Kekec , Nancy Jo Kevin , Bing Li , Songnian Lin , Craig A. Parish , Weijuan Tang
摘要: The present invention relates to tyrosine-specific functionalized insulin analogs and processes of making such tyrosine-specific functionalized insulin analogs using R-3H-1,2,4-triazoline-3,5-(4H)diones (PTAD).
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公开(公告)号:US20210163568A1
公开(公告)日:2021-06-03
申请号:US17045197
申请日:2019-04-08
发明人: Sobhana Babu Boga , Ahmet Kekec , Songnian Lin , Craig A. Parish , Weijuan Tang , Lin Yan
摘要: The present invention relates to insulin analogues and processes of making such insulin analogues by direct conversion of a free amine to an azide via diazo-transfer with an azotransfer agent.
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