公开(公告)号：US20240300955A1

公开(公告)日：2024-09-12

申请号：US18508594

申请日：2023-11-14

Applicant: Merck Sharp & Dohme LLC

Inventor： Feng XU ,  Zhuqing LIU ,  Richard DESMOND ,  Jeonghan PARK ,  Alexei KALININ ,  Birgit KOSJEK ,  Hallena STROTMAN ,  Hongmei LI ,  Johannah MONCECCHI

IPC: C07D487/04 ,  C07C215/30 ,  C07D207/08 ,  C07D207/12 ,  C12P17/10

CPC classification number: C07D487/04 ,  C07C215/30 ,  C07D207/08 ,  C07D207/12 ,  C12P17/10

Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.

公开(公告)号：US20240300960A1

公开(公告)日：2024-09-12

申请号：US18649712

申请日：2024-04-29

Applicant: Merck Sharp & Dohme LLC

Inventor： Feng XU ,  Zhuqing LIU ,  Richard DESMOND ,  Jeonghan PARK ,  Alexei KALININ ,  Birgit KOSJEK ,  Hallena STROTMAN ,  Hongmei LI ,  Johannah MONCECCHI

IPC: C07D487/04 ,  C07C215/30 ,  C07D207/08 ,  C07D207/12 ,  C12P17/10

CPC classification number: C07D487/04 ,  C07C215/30 ,  C07D207/08 ,  C07D207/12 ,  C12P17/10

Abstract: The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.