公开(公告)号：US20240025917A1

公开(公告)日：2024-01-25

申请号：US18252261

申请日：2021-11-18

申请人： Merck Sharp & Dohme LLC

发明人： Jianming Bao ,  Natalija Cernaka ,  Alan C. Cheng ,  Ying-Duo Gao ,  Salman Jabri ,  Jovan Alexander Lopez ,  Rohan Merchant ,  Anthony Ken Ogawa ,  Skylar K. Osler ,  Christopher J. Sinz ,  Phillip Patrick Sharp ,  Haiqun Tang ,  Maoqun Tian ,  Dong Xiao ,  Song Yang

IPC分类号： C07D498/10

CPC分类号： C07D498/10

摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.

公开(公告)号：US20230219962A1

公开(公告)日：2023-07-13

申请号：US17927222

申请日：2021-06-03

申请人： Jianming BAO ,  Natalija CERNAKA ,  Scott D. HOLLINGSWORTH ,  Madeleine Eileen KIEFFER ,  Simon B. LANG ,  Akash M. PATEL ,  W. Michael SEGANISH ,  Merck Sharp & Dohme LLC

发明人： Jianming Bao ,  Natalija Cernaka ,  Scott A. Hollingsworth ,  Madeleine Eileen Kieffer ,  Simon B. Lang ,  Akash M. Patel ,  W. Michael Seganish

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K39/395 ,  A61K31/519

CPC分类号： C07D487/04 ,  C07D519/00 ,  A61K39/3955 ,  A61K31/519

摘要： The present invention relates to novel Pyrazolo[4,3 -d]Pyrimidine Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one Pyrazolo[4,3-d]Pyrimidine Derivative, and methods of using the Pyrazolo[4,3-d]Pyrimidine Derivatives for treating or preventing a cellular proliferative disorder in a patient.

公开(公告)号：US20240190892A1

公开(公告)日：2024-06-13

申请号：US18550332

申请日：2022-03-16

申请人： Natalija Cernaka ,  Anthony K. OGAWA ,  Alan C. CHENG ,  Jianming BAO ,  Phillip Patrick SHARP ,  Jovan Alexander LOPEZ ,  Dong XIAO ,  Haiqun TANG ,  Merck Sharp & Dohme LLC

发明人： Natalija Cernaka ,  Anthony K. Ogawa ,  Alan C. Cheng ,  Jianming Bao ,  Phillip Patrick Sharp ,  Jovan Alexander Lopez ,  Dong Xiao ,  Haiqun Tang

IPC分类号： C07D498/20 ,  A61K31/5386 ,  A61K45/06 ,  C07D519/00

CPC分类号： C07D498/20 ,  A61K31/5386 ,  A61K45/06 ,  C07D519/00

摘要： The present invention provides a compound of formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age-related macular degeneration, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.