公开(公告)号：US11827684B2

公开(公告)日：2023-11-28

申请号：US17234844

申请日：2021-04-20

申请人： Merck Sharp & Dohme LLC

发明人： Cristina Abrahams ,  Edward Bowman ,  Xiaofan Li ,  Songnian Lin ,  Willy Solis ,  Ryan Stafford ,  Aarron Willingham ,  Alice Yam ,  Junhao Yang ,  Gang Yin

IPC分类号： A61K38/20 ,  A61K47/60 ,  C07K14/55 ,  A61K47/54 ,  A61P5/00 ,  C07K16/28 ,  A61K38/00

CPC分类号： C07K14/55 ,  A61K38/2013 ,  A61K47/545 ,  A61K47/60 ,  A61P5/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K38/00

摘要： Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor βγc dimer over binding the IL-2 receptor αβγc trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.

公开(公告)号：US20240101631A1

公开(公告)日：2024-03-28

申请号：US18484870

申请日：2023-10-11

申请人： Merck Sharp & Dohme LLC

发明人： Cristina Abrahams ,  Edward Bowman ,  Xiaofan Li ,  Songnian Lin ,  Willy Solis ,  Ryan Stafford ,  Aarron Willingham ,  Alice Yam ,  Junhao Yang ,  Gang Yin

IPC分类号： C07K14/55 ,  A61K38/20 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00 ,  C07K16/28

CPC分类号： C07K14/55 ,  A61K38/2013 ,  A61K47/545 ,  A61K47/60 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K38/00

摘要： Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor βγc dimer over binding the IL-2 receptor αβγc trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.