公开(公告)号：US20240018145A1

公开(公告)日：2024-01-18

申请号：US18015465

申请日：2021-07-22

申请人： Merck Sharp & Dohme LLC ,  COCRYSTAL PHARMA, INC.

发明人： Yonglian Zhang ,  John A. McCauley ,  Michael Man-Chu Lo ,  Liangqin Guo ,  Kake Zhao ,  Frank Bennett ,  Ronald M. Kim ,  Reynalda Keh DeJesus ,  Valerie W. Shurtleff ,  Manuel de Lera Ruiz ,  Michael Plotkin ,  Hua Su ,  James Fells ,  Brendan M. Crowley ,  Harry R. Chobanian ,  Mark W. Embrey ,  Gregori J. Morriello

IPC分类号： C07D471/14 ,  C07D491/22 ,  C07D471/04 ,  A61P31/16

CPC分类号： C07D471/14 ,  A61P31/16 ,  C07D471/04 ,  C07D491/22

摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing influenza. The compounds are cap-dependent endonuclease inhibitors.