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1.发明授权Substituted isoindolones and their use as metabotropic glutamate receptor potentiators 失效取代的异吲哚酮及其作为代谢型谷氨酸受体增强剂的用途公开(公告)号：US07868008B2
公开(公告)日：2011-01-11
申请号：US12063018
申请日：2006-02-15
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： C07D209/46 , C07D401/06 , C07D401/14 , A61K31/4035 , A61K31/454
CPC分类号： C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14
摘要： The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译： 本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如说明书中对式I所定义。 本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物在治疗中的用途。
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公开(公告)号：US08153638B2
公开(公告)日：2012-04-10
申请号：US12861336
申请日：2010-08-23
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/4035 , A61K31/427 , C07D403/14 , C07D403/02 , C07D401/02 , C07D209/44 , C07D417/02
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译： 式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如说明书中所定义，制备化合物的方法，制备中使用的新中间体，含有 化合物和化合物在治疗中的用途。
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3.发明申请Metabotropic Glutamate Receptor Oxadiazole Ligands and Their Use as Potentiators 审中-公开代谢型谷氨酸受体恶二唑配体及其用作电位器公开(公告)号：US20100280082A1
公开(公告)日：2010-11-04
申请号：US12663362
申请日：2008-06-05
申请人： Joshua Clayton , Ian Egle , James Empfield , James Folmer , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi
发明人： Joshua Clayton , Ian Egle , James Empfield , James Folmer , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi
IPC分类号： A61K31/4245 , C07D413/14 , A61K31/496 , C07D487/08 , A61P25/00 , A61P29/00 , A61P25/16 , A61P25/14 , A61P25/30 , A61P25/28
CPC分类号： C07D413/14 , C07D413/04 , C07D487/08
摘要： Compounds of Formula (I) wherein R1, R2, R3 R4 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 式（I）的化合物，其中R 1，R 2，R 3，R 4和Q如说明书中所述，药学上可接受的盐，制备方法，药物组合物及其使用方法。
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4.发明申请Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators 审中-公开双环苯并咪唑化合物及其用作代谢型谷氨酸受体电位器公开(公告)号：US20090192169A1
公开(公告)日：2009-07-30
申请号：US12225310
申请日：2007-03-29
申请人： Ian Egle , Methvin Isaac , Rebecca Urbanek , Frances M. McLaren , Sally B. Walsh , Gary B. Steelman , Dean G. Brown , David Nugiel , Deborah W. Chen , Abdelmalik Slassi , Fupeng Ma
发明人： Ian Egle , Methvin Isaac , Rebecca Urbanek , Frances M. McLaren , Sally B. Walsh , Gary B. Steelman , Dean G. Brown , David Nugiel , Deborah W. Chen , Abdelmalik Slassi , Fupeng Ma
IPC分类号： A61K31/454 , C07D401/06 , C07D403/06 , A61P35/00 , A61K31/496 , A61K31/4184
CPC分类号： C07D401/06 , C07D235/06 , C07D235/14 , C07D401/14 , C07D403/06 , C07D403/12
摘要： Compounds of Formula I: wherein A, B, D, L, R1, R2, R3, R4, m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译： 式I的化合物：其中A，B，D，L，R 1，R 2，R 3，R 4，m和n如说明书中对式I所定义。 本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物在治疗中的用途。
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公开(公告)号：US20080227794A1
公开(公告)日：2008-09-18
申请号：US12063007
申请日：2006-02-15
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/404 , A61P25/00 , C07D209/34 , C07D401/12 , C07D403/02 , C07D417/02 , A61K31/497 , A61K31/4439 , A61K31/427
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译： 式I化合物：其中R 1，R 2，R 3，R 4，R 4， 5，R 6，R 7，R 8，R 9和n如上定义 在描述中，制备化合物的方法，制备中使用的新中间体，含有该化合物的药物组合物以及该化合物在治疗中的用途。
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6.发明授权Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators 842 失效恶二唑衍生物及其作为代谢型谷氨酸受体增强剂的用途842公开(公告)号：US08377939B2
公开(公告)日：2013-02-19
申请号：US12134553
申请日：2008-06-06
申请人： Joshua Clayton , Ian Egle , James Empfield , James Folmer , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi
发明人： Joshua Clayton , Ian Egle , James Empfield , James Folmer , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi
IPC分类号： A61K31/496 , C07D413/04
CPC分类号： C07D413/04 , C07D413/14 , C07D487/08
摘要： Compounds of Formula I: wherein R1 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 式I化合物：其中R 1和Q如说明书中所述，药学上可接受的盐，制备方法，药物组合物及其使用方法。
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7.发明申请AZA-Isoindolones and Their Use as Metabotropic Glutamate Receptor Potentiators - 613 审中-公开AZA-异吲哚酮及其用作代谢型谷氨酸受体电位器 - 613公开(公告)号：US20110053953A1
公开(公告)日：2011-03-03
申请号：US12526161
申请日：2008-01-31
申请人： Abdelmalik Slassi , Methvin Isaac , Joshua Clayton , Ian Egle , Babu Joseph , Fupeng Ma
发明人： Abdelmalik Slassi , Methvin Isaac , Joshua Clayton , Ian Egle , Babu Joseph , Fupeng Ma
IPC分类号： A61K31/496 , C07D401/14 , C07D471/04 , A61K31/437 , A61P25/00
CPC分类号： C07D471/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8 and n are defined in the specification, methods for using said compounds, methods for making said compounds and pharmaceutical compositions containing said compounds.
摘要翻译： 式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8和n在本说明书中定义，使用所述化合物的方法，制备所述化合物的方法和含有所述化合物的药物组合物。
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公开(公告)号：US20100317674A1
公开(公告)日：2010-12-16
申请号：US12861336
申请日：2010-08-23
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/497 , C07D209/44 , C07D401/12 , C07D401/02 , C07D403/02 , C07D403/14 , C07D417/02 , A61K31/4035 , A61K31/4439 , A61K31/427 , A61P25/28 , A61P25/00 , A61P25/30 , A61P25/18 , A61P25/22 , A61P25/24 , A61P29/00 , A61P25/16 , A61P25/08 , A61P25/06 , A61P9/00 , A61P9/10
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译： 式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如说明书中所定义，制备化合物的方法，制备中使用的新中间体，含有 化合物和化合物在治疗中的用途。
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9.发明申请Oxadiazole Derivatives and Their Use as Metabotropic Glutamate Receptor Potentiators - 842 失效恶二唑衍生物及其作为代谢型谷氨酸受体电位器的用途 - 842公开(公告)号：US20100267740A1
公开(公告)日：2010-10-21
申请号：US12663371
申请日：2008-06-05
申请人： Joshua Clayton , Ian Egle , James Empfield , James Folmer , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi
发明人： Joshua Clayton , Ian Egle , James Empfield , James Folmer , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi
IPC分类号： A61K31/496 , C07D413/14 , A61P25/28 , A61P25/16 , A61P25/08 , A61P25/06 , A61P25/30 , A61P25/18 , A61P25/22 , A61P25/24 , C07D487/18 , A61K31/4245
CPC分类号： C07D413/04 , C07D413/14 , C07D487/08
摘要： Compounds of Formula (I) wherein R1 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 式（I）的化合物，其中R 1和Q如说明书中所述，药学上可接受的盐，制备方法，药物组合物及其使用方法。
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10.发明申请Isoindolone compounds and their use as metabotropic glutamate receptor potentiators 有权异吲哚酮化合物及其作为代谢型谷氨酸受体增强剂的用途公开(公告)号：US20090275578A1
公开(公告)日：2009-11-05
申请号：US11659149
申请日：2005-08-12
申请人： Joshua Clayton , Fupeng Ma , Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Ian Egle , James Empfield , Methvin Isaac , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Joshua Clayton , Fupeng Ma , Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Ian Egle , James Empfield , Methvin Isaac , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/40 , C07D413/02 , C07D401/14 , C07D209/34
CPC分类号： C07D471/04 , C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/10 , C07D487/04
摘要： The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译： 本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如说明书中对式I所定义。 本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物在治疗中的用途。
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