公开(公告)号：US20230383352A1

公开(公告)日：2023-11-30

申请号：US18317841

申请日：2023-05-15

Applicant: MiNDERA Corporation

Inventor： Tobin DICKERSON ,  Bradford TAFT ,  Byung-In LEE

IPC: C12Q1/6883 ,  C12Q1/6869 ,  G16B20/00 ,  G16B40/20 ,  A61M37/00

CPC classification number: C12Q1/6883 ,  C12Q1/6869 ,  G16B20/00 ,  G16B40/20 ,  A61M37/0015 ,  C12Q2600/158 ,  C12Q2600/106 ,  A61M2037/0023

Abstract: The invention is directed to reliable and efficient detection of mRNAs as well as other RNAs in living cells and its use to identify and, if desired, separate cells based on their desired characteristics Such methods greatly simplify and reduce the time necessary to carry out previously-known procedures, and offers new approaches as well, such as selecting cells that generate a particular protein or antisense oligonucleotide, generating cell lines that express multiple proteins, generating cell lines with knock-out of one or more protein, and others.

公开(公告)号：US20240425926A1

公开(公告)日：2024-12-26

申请号：US18812671

申请日：2024-08-22

Applicant: MiNDERA Corporation

Inventor： Tobin DICKERSON ,  Bradford TAFT ,  Byung-In LEE

IPC: C12Q1/6883 ,  A61M37/00

Abstract: The present disclosure provides microneedle devices and kits for extracting biomarkers from a tissue. The present disclosure provides microneedle-device-mediated extraction methods for extracting biomarkers from a lesional skin of a subject. The present disclosure also provides computer-implemented methods for predicting a patient's response to an autoimmune therapeutic drug. The present disclosure provides methods selecting a treatment for an autoimmune disease. The present disclosure also provides methods of nucleic acid analysis to prospectively predict a patient's response to a therapeutic.