公开(公告)号：US20230242914A1

公开(公告)日：2023-08-03

申请号：US17917958

申请日：2021-03-11

申请人： Michaael ZEISBERG ,  Gerd HASENFUSS ,  Elisabeth ZEISBERG ,  GEORG-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENTLICHEN RECHTS,UNIVERSITAETSMEDIZIN

发明人： Elisabeth ZEISBERG ,  Michael ZEISBERG ,  Gerd HASENFUSS ,  Xingbo XU ,  Xiaoying TAN

IPC分类号： C12N15/113 ,  C12N15/86 ,  A61K31/713 ,  A61K9/00 ,  A61P31/14

CPC分类号： C12N15/1131 ,  C12N15/86 ,  A61K31/713 ,  A61K9/0012 ,  A61P31/14 ,  C12N2710/10041 ,  C12N2750/14141

摘要： The present invention relates to a novel approach for treating coronavirus infections, particularly infections caused by MERS-CoV, SARS-CoV and SARS-CoV-2 variants. Based on effectively targeting and cleaving single stranded RNA viruses, the present invention provides Cas13d guide RNAs, to guide the Cas13d protein to a target site in the genome of humanized Coronaviridae that is conserved between MERS-CoV, SARS-CoV and SARS-CoV-2. The disclosed invention further provides an AAV vector comprising such a Cas13d guide RNA expression cassette as well as a Cas13d for treating coronavirus infections, especially COVID-19 infections.

公开(公告)号：US20230024933A1

公开(公告)日：2023-01-26

申请号：US17714500

申请日：2022-04-06

申请人： Georg-August-Universitaet Goettingen Stiftung Oeffentlichen Rechts, Universitaetsmedizin ,  Board of Regents, The University of Texas System

发明人： Michael ZEISBERG ,  Elisabeth ZEISBERG ,  Bjoern TAMPE ,  Gerhard Anton MUELLER ,  Xingbo XU ,  Desiree TAMPE ,  Raghu KALLURI

IPC分类号： A61K31/713 ,  C12Q1/6869 ,  C07K14/47 ,  C12N15/113

摘要： Provided is a method of preventing, treating or delaying progression of a disease involving aberrant fibroblast proliferation. The method involves using a compound that reduces the level of tyrosine phosphatase activity effected by the protein EYA1A in the parenchymal organ, a nucleic acid ligase IV inhibitor, or an antisense oligonucleotide against the p53-binding protein 1 (53BP1).