摘要:
Methods and formulations for inhibiting and preventing a malignant cell phenotype by administering to cells a low dose of a nitric oxide mimetic are provided.
摘要:
The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics, such as low doses, is sufficient to increase, restore or maintain nitric oxide-mediated signaling in cells so that malignant cell phenotypes, cells, tumors and/or diseases are inhibited or prevented. These methods and formulations are particularly useful in treating and preventing cancer in animals.
摘要:
The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics, such as low doses, is sufficient to increase, restore or maintain nitric oxide-mediated signaling in cells so that malignant cell phenotypes, cells, tumors and/or diseases are inhibited or prevented. These methods and formulations are particularly useful in treating and preventing cancer in animals.
摘要:
The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics, such as low doses, is sufficient to increase, restore or maintain nitric oxide-mediated signaling in cells so that malignant cell phenotypes, cells, tumors and/or diseases are inhibited or prevented. These methods and formulations are particularly useful in treating and preventing cancer in animals.
摘要:
A method for diagnosing hypoxia, endothelial dysfunction, a vascular or circulatory condition of a subject, in which the level of expression of a gene, and/or the level of a metabolite or metabolic by-product in a biological test sample is measured and compared to a control sample so as to assess the vascular condition of the subject, is described.
摘要:
A versatile chained tool set having a plurality of tools consisting of any desired working tips such as an open-end wrench, a box-end wrench, a fractional or metric wrench, socket drives, spline drives, spanner wrenches, screwdrivers of all styles, or tools such as taps, easy outs, allen wrenches or other similar tools. Each tool is formed as part of a link and each link is joined to an adjacent tool link so that the various tools are chained together. When using one of the tools, the chain can be folded or collapsed to form a rigid and strong hand piece which can then be used to apply the torque or other force necessary to operate the tool.
摘要:
An apparatus and method for using a multi-purpose tool having a handle with a shaft affixed thereto and a cylinder assembly disposed to longitudinally slide on the shaft between positions in which the shaft is fully extended or fully retracted. While in the fully retracted position, a cylinder having a plurality of chambers housing different tips may be rotated about its axis, which is offset from the shaft, until the desired tip aligns with and engages the shaft in coupling engagement. The shaft is then extended to its fully extended position, thus extending the tip and permitting free rotation of the working tip for use in performing work on a workpiece. Changing the tip requires retracting the shaft, rotating the cylinder to engage the next desired tip, and extending the shaft back to its fully extended position. The multi-purpose tool may be attached to a power tool for power driven rotation.
摘要:
A guide assembly or balance shoe assembly for slidably and pivotably mounting a window sash to a window jamb is disclosed. The guide assembly includes a shoe housing having sliding surfaces that guide the housing in the jamb channel. A sash pivot is coupled to the window sash and a locking cam is rotatably coupled within the shoe housing. The locking cam includes a sash pivot that retains the sash pivot pin. The locking cam rotates substantially with the sash pivot and the locking cam has a locking surface that is configured to engage the jamb channel when the sash pivot is rotated to a first position.
摘要:
A support device for mounting objects on a wall includes a wall bracket and a hanger. The wall bracket is mounted on a wall by means of two openings, thereby preventing rotational movement of the bracket. The wall bracket also has an elongated stabilizer. The hanger includes a hanging notch and a separate centering notch, and is attached to the object to be hung. The hanger is engaged on the wall bracket by means of the hanging notch, while the centering notch straddles the stabilizer, thus counteracting rotational forces and maintaining the object spaced from the wall. The stabilizer also acts as a centering device which is adjustably bent until the desired orientation is obtained. The object can be removed and replaced with the same orientation by means of the adjusted stabilizer.