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    Method for the normalization of sexual response and amelioration of long term genital tissue degradation
    2.
    发明申请
    Method for the normalization of sexual response and amelioration of long term genital tissue degradation 审中-公开
    性反应正常化和改善长期生殖器组织降解的方法

    公开(公告)号：US20060281752A1

    公开(公告)日：2006-12-14

    申请号：US11474783

    申请日：2006-06-26

    申请人： Jeremy Heaton ,  Michael Adams

    发明人： Jeremy Heaton ,  Michael Adams

    IPC分类号： A61K31/506 ,  A61K31/498 ,  A61K31/48 ,  A61K31/137 ,  A61K31/405

    CPC分类号： A61K31/137 ,  A61K31/00 ,  A61K31/405 ,  A61K31/473 ,  A61K31/48 ,  A61K31/498 ,  A61K31/506

    摘要： The present invention provides, in one embodiment, a method of normalizing the timing of sexual response in a mammal comprising the administration of an amount of a central nervous system sexual response initiator in an amount sufficient to produce genital vasodilation but less than the amount required to produce effective vasocongestive arousal. The method is applicable not only to adjusting or normalizing the timing of sexual response in humans, but in the breeding of valuable commercial animals such as horses, cattle, sheep, swine and the like and domesticated pets such as dogs and cats. In an alternative embodiment, the present invention provides a method for the prophylactic treatment of long-term tissue degradation in the genital organs comprising the administration to a mammal of a central nervous system sexual response initiator in an amount sufficient to produce genital vasodilation but less than the amount required to produce effective vasocongestive arousal. The preferred central nervous system sexual response initiator is apomorphine or a pharmaceutically acceptable acid addition salt thereof.

    摘要翻译： 在一个实施方案中，本发明提供了使哺乳动物的性反应时间正常化的方法，其包括以足以产生生殖器血管舒张的量施用一定量的中枢神经系统性反应引发剂，但小于 产生有效的血管舒张觉醒。 该方法不仅适用于调整或规范人类性反应的时间，而且适用于马，牛，绵羊，猪等有价值的商业动物的养殖，以及驯养宠物如狗和猫。 在替代实施方案中，本发明提供了一种用于预防性治疗生殖器官中的长期组织降解的方法，其包括以足以产生生殖器血管舒张的量施用给哺乳动物的中枢神经系统性反应引发剂，但少于 产生有效的血管舒张功能所需的量。 优选的中枢神经系统性反应引发剂是阿朴吗啡或其药学上可接受的酸加成盐。

    Microdose therapy
    3.
    发明申请
    Microdose therapy 失效
    微剂量治疗

    公开(公告)号：US20050197300A1

    公开(公告)日：2005-09-08

    申请号：US10460061

    申请日：2003-06-11

    申请人： Michael Adams ,  Jeremy Heaton ,  James Banting

    发明人： Michael Adams ,  Jeremy Heaton ,  James Banting

    IPC分类号： A61K45/00 ,  A61K31/04 ,  A61K31/16 ,  A61K31/198 ,  A61K31/21 ,  A61K31/295 ,  A61K31/34 ,  A61K31/5377 ,  A61K38/06 ,  A61P15/00 ,  A61P15/10 ,  A61P43/00 ,  A61K38/05

    CPC分类号： A61K38/063 ,  A61K31/04 ,  A61K31/16 ,  A61K31/198 ,  A61K31/21 ,  A61K31/295 ,  A61K31/34 ,  A61K31/5377

    摘要： Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (½ to 1/20) of those known to induce vasodilation in “normal” circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.

    摘要翻译： 提供了用于治疗与血管紧张度局部不平衡相关的血管病变的方法，其被假设主要是由于内皮素（ET）升高。 所述方法包括给予一氧化氮（NO），能够提供NO的试剂，例如NO供体，活化脯氨酸环化酶的试剂，例如YC-1，或延长内源性NO或环鸟苷酸单磷酸的作用的试剂 cGMP;第二信使分子），例如磷酸二酯酶（PDE）抑制剂。 根据本发明，通过本领域已知的任何途径，以最小剂量或微量剂量施用这些药剂，以提供已知诱导血管舒张的剂量的约一半至约二十分之一（1/2至1/20）的剂量 “正常”循环。 低剂量的这些药物通过恢复血管紧张度的平衡，同时在正常脉管系统中几乎没有全身作用，有效地缓解与NO产生减少或NO作用减弱相关的血管病症。