专利检索 ap:("Michael E. Hepperle" OR "Julie Fields Liu" OR "Francois Soucy" OR "Yingchun Ye" OR "Robert S. Murray" OR "Raman Prakash" OR "Jeremy D. Little" OR "Alfredo Castro" OR "Hormoz Mazdiyasni" OR "Paul E. Fleming" OR "Dominic Reynolds") AND inv:"Yingchun Ye" 第 1 页

1.

发明申请
BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE 审中-公开
标题翻译：用于治疗炎症疾病的BETA-CARBOLINES有用

公开(公告)号：US20100093713A1

公开(公告)日：2010-04-15

申请号：US12640335

申请日：2009-12-17

申请人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds

发明人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds

IPC分类号： A61K31/541 , C07D471/04 , A61P35/04 , A61P37/00 , A61K31/5377 , A61P29/00 , A61K31/501 , A61K31/437 , C07D295/10

CPC分类号： C07D265/30 , C07D471/04

摘要： This invention provides beta-carboline compounds of formula wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.

摘要翻译： 本发明提供下式的β-咔啉化合物，其中环A是取代的吡啶基，嘧啶基，吗啉基，哌啶基，哌嗪基，吡咯烷基，吡喃基，四氢呋喃基，环己基，环戊基或硫代吗啉基，R1，R2和R3如说明书中所述。这些化合物是可用于治疗IKK-2介导的疾病如炎性疾病和癌症的IKK-2抑制剂。

2.

发明授权
Beta-carbolines useful for treating inflammatory disease 有权
标题翻译： β-咔啉可用于治疗炎性疾病

公开(公告)号：US07727985B2

公开(公告)日：2010-06-01

申请号：US10821545

申请日：2004-04-09

申请人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds

发明人： Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds

IPC分类号： A61K31/5377 , C07D413/14 , C07D413/02

CPC分类号： C07D265/30 , C07D471/04

摘要： This invention provides beta-carboline compounds of formula I: wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.

摘要翻译： 本发明提供式I的β-咔啉化合物：其中环A是取代的吡啶基，嘧啶基，吗啉基，哌啶基，哌嗪基，吡咯烷基，吡喃基，四氢呋喃基，环己基，环戊基或硫代吗啉基，R1，R2和R3如规范。这些化合物是可用于治疗IKK-2介导的疾病如炎性疾病和癌症的IKK-2抑制剂。