公开(公告)号：US20120225954A1

公开(公告)日：2012-09-06

申请号：US13223862

申请日：2011-09-01

申请人： Michael F. Moran ,  Thomas Kislinger ,  Ming-Sound Tsao ,  Yuhong Wei ,  Jiefei Tong ,  Paul Taylor

发明人： Michael F. Moran ,  Thomas Kislinger ,  Ming-Sound Tsao ,  Yuhong Wei ,  Jiefei Tong ,  Paul Taylor

IPC分类号： G01N27/62 ,  A61P35/00 ,  A61K35/00 ,  G01N33/574 ,  C40B30/10

CPC分类号： G01N33/57423 ,  G01N2333/4742 ,  G01N2800/50 ,  G01N2800/60

摘要： The disclosure includes a method of screening for, diagnosing or detecting non-small cell lung carcinoma or an increased likelihood of developing non-small cell lung carcinoma in a subject. The method comprises: (a) determining the level of at least one biomarker in a test sample from the subject wherein the at least one biomarker is selected from the biomarkers set out in Table 2, 4A, 4B, 6 and/or 7; and (b) comparing the level of the at least one biomarker in the test sample with a control; wherein detecting a difference in the level of the at least one biomarker in the test sample compared to the control is indicative of whether the subject has or does not have non-small cell lung carcinoma or an increased likelihood of developing non-small cell lung carcinoma.

摘要翻译： 本公开包括筛选，诊断或检测非小细胞肺癌或增加受试者中发展非小细胞肺癌的可能性的方法。 该方法包括：（a）测定来自受试者的测试样品中至少一种生物标志物的水平，其中所述至少一种生物标志物选自表2,4A，4B，6和/或7中所示的生物标志物; 和（b）将测试样品中的至少一种生物标志物的水平与对照进行比较; 其中检测所述测试样品中所述至少一种生物标记物的水平与所述对照相比的差异指示所述受试者是否具有非小细胞肺癌或增加发生非小细胞肺癌的可能性 。