公开(公告)号：US06685962B2

公开(公告)日：2004-02-03

申请号：US10157325

申请日：2002-05-29

申请人： Michael Friedman ,  Eytan Klausner ,  Eran Lavy ,  Amnon Hoffman

发明人： Michael Friedman ,  Eytan Klausner ,  Eran Lavy ,  Amnon Hoffman

IPC分类号： A61K952

CPC分类号： A61K9/2086

摘要： Pharmaceutical gastroretentive drug delivery systems for the controlled release of an active agent in the gastrointestinal tract are disclosed, which comprise: (a) a single- or multi-layered matrix comprising a polymer that does not retain in the stomach more than a conventional dosage form selected from (1) degradable polymers that may be hydrophilic polymers not instantly soluble in gastric fluids, enteric polymers substantially insoluble at pH less than 5.5 and/or hydrophobic polymers and mixtures thereof; (2) non-degradable polymers; and any mixtures of (1) and (2); (b) a continuous or non-continuous membrane comprising at least one polymer having a substantial mechanical strength; and (c) a drug; wherein the matrix when affixed or attached to the membrane prevents evacuation from the stomach of the delivery system for a period of time of from about 3 to about 24 hours.

摘要翻译： 公开了用于在胃肠道中控制释放活性剂的药物胃滞留药物递送系统，其包括：（a）包含不比常规剂型保留在胃中的聚合物的单层或多层基质 选自（1）可以是亲水性聚合物的可降解聚合物，其不能立即溶于胃液，在pH小于5.5时基本上不溶解的肠溶聚合物和/或疏水性聚合物及其混合物; （2）不可降解聚合物; 和（1）和（2）的任何混合物; （b）包含至少一种具有相当机械强度的聚合物的连续或非连续膜; 和（c）药物; 其中当固定或连接到膜上时的基质防止从输送系统的胃排出约3至约24小时的时间。