公开(公告)号：US20060118514A1

公开(公告)日：2006-06-08

申请号：US11289660

申请日：2005-11-28

申请人： Michael Little ,  Charles McLaughlin

发明人： Michael Little ,  Charles McLaughlin

IPC分类号： C23F1/00

CPC分类号： B82Y30/00 ,  G02B5/3058

摘要： A wire grid polarizer may be fabricated by forming plurality of substantially-straight metallic lines of predetermined periodicity Λ on a thin film substrate A plurality of substantially straight nanometer-scale periodic surface relief structures is created on a surface of the substrate. The periodic surface relief structures cover a region greater than about 4 centimeters in length and greater than about 4 centimeters in width, wherein the periodicity Λ is between about 10 nanometers and about 500 nanometers. One or more layers of material are formed on the periodic relief structures. The one or more layers include one or more conductor materials that form the plurality of substantially straight metallic lines over a region of the substrate greater than about 4 centimeters in length and greater than about 4 centimeters in width.

公开(公告)号：US20060263406A1

公开(公告)日：2006-11-23

申请号：US11381044

申请日：2006-05-01

申请人： Mark Lyles ,  Charles McLaughlin ,  Glenn Halff ,  William Mallow

发明人： Mark Lyles ,  Charles McLaughlin ,  Glenn Halff ,  William Mallow

IPC分类号： A61F2/00

CPC分类号： A61L27/54 ,  A61L27/56 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/604

摘要： An implantable infection shield and system for drug delivery in vascular tissue includes a relatively non-biodegradable porous linked fibrous biomaterial which controls and directs cell growth and angiogenesis from adjacent vascular tissue into the implant. Infection shield embodiments stimulate cell growth and angiogenesis from adjacent vascular tissue which effectively blocks passage of pathogenic microorganisms along percutaneously implanted objects. In embodiments for drug delivery, a reservoir of the same biomaterial may contain either (1) a cell culture system enclosed within a porous sealable interior chamber or (2) a biodegradable matrix in which one or more drugs are dispersed. After implantation of a reservoir of the first embodiment in an organism, cultured cells obtain food and oxygen via diffusion in tissue fluid through the porous walls of the interior chamber, while metabolic products, including drugs, diffuse away from the cell culture in an analogous manner. In a reservoir of the second embodiment, a biodegradable matrix substantially fills the pores (voids), and progressive dissolution of the matrix releases one or more drugs into surrounding tissue fluid. Reservoirs of either embodiment comprise a plurality of voids of a predetermined size effective for stimulating angiogenesis from the surrounding vascular tissue into at least a portion of the reservoir. The reservoir thus acts to couple a source: of drugs to the circulatory system of the organism.

摘要翻译： 用于在血管组织中药物递送的可植入感染屏蔽和系统包括相对不可生物降解的多孔连接的纤维生物材料，其控制并引导细胞生长和血管生成从相邻血管组织进入植入物。 感染屏障实施例刺激来自相邻血管组织的细胞生长和血管生成，其有效地阻止病原微生物沿着经皮植入物体的通过。 在用于药物递送的实施方案中，相同生物材料的储库可以包含（1）包封在多孔可密封的内部室内的细胞培养系统或（2）其中分散有一种或多种药物的生物可降解基质。 在将第一实施方案的储存器植入生物体之后，培养的细胞通过内部室的多孔壁在组织液中的扩散而获得食物和氧气，而代谢产物（包括药物）以类似的方式从细胞培养物扩散 。 在第二实施方案的储存器中，生物降解基质基本上填充孔（空隙），并且基质的逐渐溶解将一种或多种药物释放到周围的组织液中。 任一实施方案的储库包括多个预定尺寸的空隙，其有效刺激来自周围血管组织的血管发生至储存器的至少一部分。 因此，水库用来将药物来源：生物体的循环系统。

公开(公告)号：US20050027668A1

公开(公告)日：2005-02-03

申请号：US10631054

申请日：2003-07-31

申请人： Robert Foster ,  Casey McCreary ,  Charles McLaughlin ,  Christine Wang

发明人： Robert Foster ,  Casey McCreary ,  Charles McLaughlin ,  Christine Wang

IPC分类号： G06F7/00

CPC分类号： G06F8/656 ,  Y10S707/99943

摘要： A method, system, and computer program product are disclosed for managing an application's persistent data across multiple different release versions of the application. A format for a memory area is defined wherein the persistent data will be stored according to a first release version of the application. The format is organized to permit the application running at different release versions to access the memory area. The memory area is accessed using the application that is running at a second release version. The memory area is divided into individually accessible sections. The format includes a template file for each section for each release version.

摘要翻译： 公开了一种方法，系统和计算机程序产品，用于跨应用程序的多个不同版本的版本管理应用程序的持久数据。 定义了存储区域的格式，其中永久数据将根据应用的第一版本版本被存储。 该格式被组织以允许在不同发行版本上运行的应用程序访问内存区域。 使用正在运行的第二个版本的应用程序来访问内存区域。 存储区域分为单独访问的区段。 该格式包括每个版本的每个部分的模板文件。