CELL THERAPY FOR CHRONIC STROKE
    3.
    发明申请
    CELL THERAPY FOR CHRONIC STROKE 审中-公开
    慢性淋巴细胞疗法

    公开(公告)号:US20140099286A1

    公开(公告)日:2014-04-10

    申请号:US14037990

    申请日:2013-09-26

    IPC分类号: A61K35/30

    CPC分类号: A61K35/30 A61K48/00

    摘要: A method of treating stroke in a patient who has undergone a stroke comprising administering at least 2 million suitable neuronal cells in at least one brain area involved in the stroke. The method comprises the step of using a twist drill or a burr to form a hole in the skull through which the cells could be administered. Exemplary cells are hNT neuronal cells, HCN-1 cells, fetal pig cells, neural crest cells, neural stem cells, or a combination thereof. Also disclosed herein is a pharmaceutical composition of 95% pure hNT neuronal cells, which composition further includes a vial containing PBS and human neuronal cells. This vial is provided in a container with liquid nitrogen, whereby the composition is frozen and maintained at −170° C. before use. Also disclosed are methods of improving speech, cognitive, sensory, and motor function in a person who has experienced brain damage which interferes with function by administering a sterile composition of a sufficient number of neuronal cells or neural stem cells to the damaged area. Also disclosed is a method of replacing central nervous cells lost to neurodegenerative disease, trauma, ischemia or poisoning.

    摘要翻译: 一种治疗已经发生中风的患者的中风的方法,包括在涉及中风的至少一个脑区域中施用至少200万个合适的神经元细胞。 该方法包括使用麻花钻或毛刺在颅骨中形成可以给予细胞的孔。 示例性细胞是hNT神经元细胞,HCN-1细胞,胎儿猪细胞,神经嵴细胞,神经干细胞或其组合。 本文还公开了95%纯的hNT神经元细胞的药物组合物,该组合物还包括含有PBS和人神经元细胞的小瓶。 将该小瓶设置在具有液氮的容器中,由此在使用前将组合物冷冻并保持在-170℃。 还公开了通过向受损区域施用足够数量的神经元细胞或神经干细胞的无菌组合物来改善经历脑功能损害的人的语言,认知,感觉和运动功能的方法。 还公开了一种替代神经变性疾病,创伤,缺血或中毒损失的中枢神经细胞的方法。